cvd-logocvd - Molecule ID A7476

geneALPL
nameAlkaline phosphatase, tissue-nonspecific isozyme precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PPBT_HUMANP05186ENSG00000162551249Hs.75431146300, 171760, 241500, 241510

Functions and classifications

GOC:anchored component of membrane, C:extracellular matrix, C:extracellular membrane-bounded organelle, C:extracellular space, C:integral component of membrane, C:plasma membrane, F:alkaline phosphatase activity, F:metal ion binding, F:pyrophosphatase activity, P:cellular response to organic cyclic compound, P:cementum mineralization, P:developmental process involved in reproduction, P:endochondral ossification, P:response to antibiotic, P:response to glucocorticoid, P:response to lipopolysaccharide, P:response to vitamin D, P:skeletal system development, P:dephosphorylation, F:phosphatase activity, C:anchored to membrane, C:integral to membrane, P:response to glucocorticoid stimulus
UniProtAlternative splicing, Biomineralization, Cell membrane, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, GPI-anchor, Hydrolase, Lipoprotein, Magnesium, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Signal, Transmembrane, Zinc
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.185<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))1.187<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)0.886<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))1.134<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.279<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))2.346<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))0.724<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.339<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project