cvd-logocvd - Molecule ID A5821

geneARG1
nameArginase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARGI1_HUMANP05089ENSG00000118520383Hs.440934207800, 608313

Functions and classifications

GOC:external side of plasma membrane, C:extracellular space, C:interleukin-6 receptor complex, F:cytokine activity, F:growth factor activity, F:interleukin-6 receptor binding, P:acute-phase response, P:aging, P:bone remodeling, P:branching involved in salivary gland morphogenesis, P:cell growth, P:cell redox homeostasis, P:cellular response to hydrogen peroxide, P:defense response to Gram-negative bacterium, P:defense response to Gram-positive bacterium, P:defense response to protozoan, P:defense response to virus, P:endocrine pancreas development, P:epithelial cell proliferation involved in salivary gland morphogenesis, P:glucagon secretion, P:hepatic immune response, P:humoral immune response, P:interleukin-6-mediated signaling pathway, P:monocyte chemotaxis, P:muscle cell cellular homeostasis, P:negative regulation of apoptotic process, P:negative regulation of cell proliferation, P:negative regulation of chemokine biosynthetic process, P:negative regulation of collagen biosynthetic process, P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:negative regulation of cytokine secretion, P:negative regulation of fat cell differentiation, P:negative regulation of gluconeogenesis, P:negative regulation of hormone secretion, P:negative regulation of lipid storage, P:negative regulation of muscle organ development, P:negative regulation of neuron death, P:negative regulation of protein kinase activity, P:neuron projection development, P:neutrophil apoptotic process, P:neutrophil mediated immunity, P:platelet activation, P:positive regulation of acute inflammatory response, P:positive regulation of B cell activation, P:positive regulation of chemokine production, P:positive regulation of DNA replication, P:positive regulation of epithelial cell proliferation, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of immunoglobulin secretion, P:positive regulation of interleukin-6 production, P:positive regulation of leukocyte chemotaxis, P:positive regulation of MAPK cascade, P:positive regulation of neuron differentiation, P:positive regulation of nitric oxide biosynthetic process, P:positive regulation of osteoblast differentiation, P:positive regulation of peptidyl-serine phosphorylation, P:positive regulation of protein import into nucleus, translocation, P:positive regulation of protein kinase B signaling, P:positive regulation of sequence-specific DNA binding transcription factor activity, P:positive regulation of smooth muscle cell proliferation, P:positive regulation of STAT protein import into nucleus, P:positive regulation of T cell proliferation, P:positive regulation of T-helper 2 cell differentiation, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of translation, P:positive regulation of transmission of nerve impulse, P:positive regulation of type B pancreatic cell apoptotic process, P:positive regulation of tyrosine phosphorylation of Stat3 protein, P:regulation of angiogenesis, P:regulation of cell shape, P:regulation of circadian sleep/wake cycle, non-REM sleep, P:regulation of vascular endothelial growth factor production, P:response to amino acid, P:response to antibiotic, P:response to caffeine, P:response to calcium ion, P:response to cold, P:response to drug, P:response to electrical stimulus, P:response to glucocorticoid, P:response to heat, P:response to insulin, P:response to lipopolysaccharide, P:response to mechanical stimulus, P:response to nutrient levels, P:response to peptidoglycan, P:T cell activation, P:immune response, P:response to wounding, C:extracellular region, P:muscle cell homeostasis, P:positive regulation of protein kinase B signaling cascade, P:response to amino acid stimulus, P:response to glucocorticoid stimulus, P:response to insulin stimulus
UniProt3D-structure, Alternative splicing, Arginine metabolism, Complete proteome, Cytoplasm, Disease mutation, Hydrolase, Manganese, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Urea cycle
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseP-valueDetectionPubMed/DOI
Exp26690514Homo sapiens24bloodwholeCAD (Coronary artery disease (CAD))9.25E-03Gene-array26690514
Exp26690514Homo sapiens24bloodwholeCAD (Coronary artery disease (CAD))9.82E-03Gene-array26690514

Compile date 02-09-2018© C/VD project