cvd-logocvd - Molecule ID A5815

geneAPEX1, APE, APEX
nameDNA-(apurinic or apyrimidinic site) lyase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APEX1_HUMANP27695ENSG00000100823328Hs.73722107748

Functions and classifications

GOC:centrosome, C:endoplasmic reticulum, C:mitochondrion, C:nuclear speck, C:nucleolus, C:perinuclear region of cytoplasm, C:ribosome, C:transcription factor complex, F:3'-5' exonuclease activity, F:chromatin DNA binding, F:damaged DNA binding, F:DNA-(apurinic or apyrimidinic site) lyase activity, F:metal ion binding, F:oxidoreductase activity, F:phosphodiesterase I activity, F:RNA binding, F:RNA-DNA hybrid ribonuclease activity, F:site-specific endodeoxyribonuclease activity, specific for altered base, F:transcription coactivator activity, F:transcription corepressor activity, F:uracil DNA N-glycosylase activity, P:aging, P:base-excision repair, P:cell redox homeostasis, P:cellular response to cAMP, P:cellular response to hydrogen peroxide, P:cellular response to peptide hormone stimulus, P:DNA demethylation, P:DNA recombination, P:negative regulation of smooth muscle cell migration, P:positive regulation of DNA repair, P:positive regulation of G1/S transition of mitotic cell cycle, P:regulation of mRNA stability, P:regulation of transcription, DNA-templated, P:response to drug, P:transcription, DNA-templated, C:nucleus, F:DNA binding, F:endonuclease activity, P:DNA repair, P:nucleic acid phosphodiester bond hydrolysis, C:mitochondrion, F:endoribonuclease activity, P:RNA phosphodiester bond hydrolysis, endonucleolytic, C:intracellular, F:ribonuclease H activity, P:regulation of transcription, DNA-dependent, P:transcription, DNA-dependent, C:cytoplasm, C:centrosome, C:endoplasmic reticulum, C:mitochondrion, C:nuclear speck, C:nucleolus, C:perinuclear region of cytoplasm, C:ribosome, C:transcription factor complex, F:3'-5' exonuclease activity, F:chromatin DNA binding, F:damaged DNA binding, F:DNA-(apurinic or apyrimidinic site) lyase activity, F:metal ion binding, F:oxidoreductase activity, F:phosphodiesterase I activity, F:RNA binding, F:RNA-DNA hybrid ribonuclease activity, F:site-specific endodeoxyribonuclease activity, specific for altered base, F:transcription coactivator activity, F:transcription corepressor activity, F:uracil DNA N-glycosylase activity, P:aging, P:base-excision repair, P:cell redox homeostasis, P:cellular response to cAMP, P:cellular response to hydrogen peroxide, P:cellular response to peptide hormone stimulus, P:DNA demethylation, P:DNA recombination, P:negative regulation of smooth muscle cell migration, P:positive regulation of DNA repair, P:positive regulation of G1/S transition of mitotic cell cycle, P:regulation of mRNA stability, P:regulation of transcription, DNA-templated, P:response to drug, P:transcription, DNA-templated, C:nucleus, F:DNA binding, F:endonuclease activity, P:DNA repair, P:nucleic acid phosphodiester bond hydrolysis, C:mitochondrion, F:endoribonuclease activity, P:RNA phosphodiester bond hydrolysis, endonucleolytic, C:intracellular, F:ribonuclease H activity, P:regulation of transcription, DNA-dependent, P:transcription, DNA-dependent, C:cytoplasm
UniProt3D-structure, Acetylation, Activator, Cleavage on pair of basic residues, Complete proteome, Cytoplasm, Direct protein sequencing, Disulfide bond, DNA damage, DNA recombination, DNA repair, DNA-binding, Endonuclease, Endoplasmic reticulum, Exonuclease, Hydrolase, Lyase, Magnesium, Metal-binding, Mitochondrion, Nuclease, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repressor, RNA-binding, S-nitrosylation, Transcription, Transcription regulation, Ubl conjugation, Plasmid
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17106732Homo sapiens12heartendocardiumDCMi (Inflammatory dilated cardiomyopathy (DCMi)) 2.92E-04Gene-array17106732
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.110<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.799<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)1.141<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))0.462<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.223<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.713<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))0.759<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.000<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project