cvd-logocvd - Molecule ID A5766

geneALDH4A1, ALDH4, P5CDH
nameDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AL4A1_HUMANP30038ENSG000001594238659Hs.77448239510, 606811

Functions and classifications

GOC:mitochondrial matrix, F:1-pyrroline-5-carboxylate dehydrogenase activity, F:aldehyde dehydrogenase (NAD) activity, F:electron carrier activity, P:4-hydroxyproline catabolic process, P:cellular nitrogen compound metabolic process, P:proline biosynthetic process, P:proline catabolic process, P:proline catabolic process to glutamate, F:oxidoreductase activity, F:1-pyrroline-5-carboxylate dehydrogenase activity, F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor, C:mitochondrial matrix, F:1-pyrroline-5-carboxylate dehydrogenase activity, F:aldehyde dehydrogenase (NAD) activity, F:electron carrier activity, P:4-hydroxyproline catabolic process, P:cellular nitrogen compound metabolic process, P:proline biosynthetic process, P:proline catabolic process, P:proline catabolic process to glutamate, F:oxidoreductase activity, F:1-pyrroline-5-carboxylate dehydrogenase activity, F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Direct protein sequencing, Disease mutation, Mitochondrion, NAD, Oxidoreductase, Polymorphism, Proline metabolism, Reference proteome, Transit peptide
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21417265Homo sapiens17heartmyocardiumDCM (Dilated cardiomyopathy)1.8001.62E-07LC-MS/MS21417265

Compile date 02-09-2018© C/VD project