cvd-logocvd - Molecule ID A5694

geneACSL3, ACS3, FACL3
nameLong-chain-fatty-acid--CoA ligase 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACSL3_HUMANO95573ENSG000001239832181Hs.655772602371

Functions and classifications

GOC:endoplasmic reticulum, C:endoplasmic reticulum membrane, C:Golgi apparatus, C:integral component of membrane, C:lipid particle, C:mitochondrial outer membrane, C:perinuclear region of cytoplasm, C:peroxisomal membrane, F:ATP binding, F:long-chain fatty acid-CoA ligase activity, P:brain development, P:fatty acid biosynthetic process, P:long-chain fatty acid import, P:positive regulation of Golgi to plasma membrane protein transport, P:positive regulation of phosphatidylcholine biosynthetic process, P:positive regulation of secretion, P:response to nutrient, P:response to organic cyclic compound, P:very-low-density lipoprotein particle assembly, F:catalytic activity, F:ligase activity, C:integral to membrane, P:long-chain fatty-acyl-CoA biosynthetic process, P:triglyceride biosynthetic process, P:long-chain fatty acid metabolic process, C:endoplasmic reticulum, C:endoplasmic reticulum membrane, C:Golgi apparatus, C:integral component of membrane, C:lipid particle, C:mitochondrial outer membrane, C:perinuclear region of cytoplasm, C:peroxisomal membrane, F:ATP binding, F:long-chain fatty acid-CoA ligase activity, P:brain development, P:fatty acid biosynthetic process, P:long-chain fatty acid import, P:positive regulation of Golgi to plasma membrane protein transport, P:positive regulation of phosphatidylcholine biosynthetic process, P:positive regulation of secretion, P:response to nutrient, P:response to organic cyclic compound, P:very-low-density lipoprotein particle assembly, F:catalytic activity, F:ligase activity, C:integral to membrane, P:long-chain fatty-acyl-CoA biosynthetic process, P:triglyceride biosynthetic process, P:long-chain fatty acid metabolic process
UniProtATP-binding, Complete proteome, Endoplasmic reticulum, Fatty acid metabolism, Ligase, Lipid metabolism, Magnesium, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Nucleotide-binding, Peroxisome, Phosphoprotein, Polymorphism, Reference proteome, Signal-anchor, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseP-valueDetectionPubMed/DOI
Exp15769906aHomo sapiens19heartmyocardiumNICM (Pre-LVAD, nonischemic cardiomyopathy)1.02E-06Gene-array15769906
Exp15769906aHomo sapiens19heartmyocardiumNICM (Pre-LVAD, nonischemic cardiomyopathy)1.33E-06Gene-array15769906

Compile date 02-09-2018© C/VD project