cvd-logocvd - Molecule ID A5693

geneACSL1, FACL1, FACL2
nameLong-chain-fatty-acid--CoA ligase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACSL1_HUMANP33121ENSG000001517262180Hs.406678152425, 152426

Functions and classifications

GOC:mitochondrial respiratory chain complex I, F:NADH dehydrogenase (ubiquinone) activity, P:mitochondrial electron transport, NADH to ubiquinone, P:small molecule metabolic process, C:mitochondrial inner membrane
UniProtAcetylation, Alternative splicing, ATP-binding, Complete proteome, Direct protein sequencing, Endoplasmic reticulum, Fatty acid metabolism, Ligase, Lipid metabolism, Magnesium, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Nitration, Nucleotide-binding, Peroxisome, Phosphoprotein, Reference proteome, Signal-anchor, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.191<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.774<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)0.836<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))0.858<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.293<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.403<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))0.840<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.000<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project