cvd-logocvd - Molecule ID A5670

geneACO1, IRP1, IREB1
nameIron-responsive element binding protein 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACOC_HUMANP21399ENSG0000012272948Hs.567229100880

Functions and classifications

GOC:cytosol, C:endoplasmic reticulum, C:Golgi apparatus, C:mitochondrion, F:4 iron, 4 sulfur cluster binding, F:aconitate hydratase activity, F:iron-responsive element binding, F:metal ion binding, P:cellular iron ion homeostasis, P:citrate metabolic process, P:intestinal absorption, P:post-embryonic development, P:regulation of translation, P:response to iron(II) ion, P:tricarboxylic acid cycle, P:metabolic process, P:regulation of translation, F:4 iron, 4 sulfur cluster binding, P:metabolic process, F:citrate hydro-lyase (cis-aconitate-forming) activity, F:isocitrate hydro-lyase (cis-aconitate-forming) activity, F:mRNA 5'-UTR binding, C:cytosol, C:endoplasmic reticulum, C:Golgi apparatus, C:mitochondrion, F:4 iron, 4 sulfur cluster binding, F:aconitate hydratase activity, F:iron-responsive element binding, F:metal ion binding, P:cellular iron ion homeostasis, P:citrate metabolic process, P:intestinal absorption, P:post-embryonic development, P:regulation of translation, P:response to iron(II) ion, P:tricarboxylic acid cycle, P:metabolic process, P:regulation of translation, F:4 iron, 4 sulfur cluster binding, P:metabolic process, F:citrate hydro-lyase (cis-aconitate-forming) activity, F:isocitrate hydro-lyase (cis-aconitate-forming) activity, F:mRNA 5'-UTR binding
UniProt3D-structure, 4Fe-4S, Complete proteome, Cytoplasm, Direct protein sequencing, Iron, Iron-sulfur, Lyase, Metal-binding, Polymorphism, Reference proteome, RNA-binding, Tricarboxylic acid cycle
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21417265Homo sapiens17heartmyocardiumDCM (Dilated cardiomyopathy)1.5000.0003084LC-MS/MS21417265

Compile date 02-09-2018© C/VD project