cvd-logocvd - Molecule ID A5657

geneACADVL, VLCAD
nameAcyl-CoA dehydrogenase, very-long-chain specific, mitochondrial precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACADV_HUMANP49748ENSG0000007277837Hs.437178201475, 609575

Functions and classifications

GOC:acrosomal membrane, C:apical plasma membrane, C:basolateral plasma membrane, C:caveola, C:cell cortex, C:cilium, C:endocytic vesicle membrane, C:endoplasmic reticulum, C:endosome, C:Golgi membrane, C:integral component of plasma membrane, C:lipid particle, C:perinuclear region of cytoplasm, C:protein complex, F:cholesterol binding, F:patched binding, F:peptidase activator activity, F:protein complex scaffold, P:angiogenesis, P:apoptotic signaling pathway, P:blood coagulation, P:calcium ion transport, P:caveola assembly, P:caveolin-mediated endocytosis, P:cellular response to hyperoxia, P:cellular response to starvation, P:cholesterol homeostasis, P:cholesterol transport, P:cytosolic calcium ion homeostasis, P:inactivation of MAPK activity, P:lactation, P:leukocyte migration, P:lipid storage, P:maintenance of protein location in cell, P:mammary gland involution, P:MAPK cascade, P:membrane depolarization, P:negative regulation of anoikis, P:negative regulation of BMP signaling pathway, P:negative regulation of canonical Wnt signaling pathway, P:negative regulation of cytokine-mediated signaling pathway, P:negative regulation of endothelial cell proliferation, P:negative regulation of epithelial cell differentiation, P:negative regulation of JAK-STAT cascade, P:negative regulation of nitric oxide biosynthetic process, P:negative regulation of nitric-oxide synthase activity, P:negative regulation of peptidyl-serine phosphorylation, P:negative regulation of protein binding, P:negative regulation of protein ubiquitination, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of tyrosine phosphorylation of Stat5 protein, P:nitric oxide homeostasis, P:nitric oxide metabolic process, P:positive regulation of calcium ion transport into cytosol, P:positive regulation of canonical Wnt signaling pathway, P:positive regulation of extrinsic apoptotic signaling pathway, P:positive regulation of intrinsic apoptotic signaling pathway, P:positive regulation of metalloenzyme activity, P:positive regulation of peptidyl-serine phosphorylation, P:positive regulation of vasoconstriction, P:protein homooligomerization, P:receptor internalization involved in canonical Wnt signaling pathway, P:regulation of blood coagulation, P:regulation of fatty acid metabolic process, P:regulation of nitric-oxide synthase activity, P:regulation of smooth muscle contraction, P:regulation of the force of heart contraction by chemical signal, P:response to calcium ion, P:response to estrogen, P:response to hypoxia, P:response to ischemia, P:response to progesterone, P:skeletal muscle tissue development, P:small molecule metabolic process, P:T cell costimulation, P:triglyceride metabolic process, P:vasculogenesis, P:vasoconstriction, P:vesicle organization, P:viral process, P:cellular calcium ion homeostasis, P:protein localization, C:basal plasma membrane, C:cell surface, C:cytosol, C:flagellum, C:focal adhesion, C:integral to plasma membrane, C:mitochondrion, P:cholesterol efflux, P:microtubule polymerization, P:negative regulation of canonical Wnt receptor signaling pathway, P:positive regulation of canonical Wnt receptor signaling pathway, P:positive regulation of endocytosis, P:positive regulation of microtubule polymerization, P:receptor internalization involved in canonical Wnt receptor signaling pathway, P:response to drug, P:response to estrogen stimulus, P:response to gamma radiation, P:response to glucocorticoid stimulus, P:response to mechanical stimulus, P:response to nutrient, P:response to progesterone stimulus, P:virus-host interaction, P:positive regulation of signal transduction
UniProt3D-structure, Acetylation, Alternative splicing, Cardiomyopathy, Complete proteome, Disease mutation, FAD, Fatty acid metabolism, Flavoprotein, Isopeptide bond, Lipid metabolism, Membrane, Mitochondrion, Mitochondrion inner membrane, Oxidoreductase, Polymorphism, Reference proteome, S-nitrosylation, Transit peptide, Ubl conjugation
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.211<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))1.955<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)1.119<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))1.166<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.301<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))1.436<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))1.239<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.000<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project