cvd-logocvd - Molecule ID A560E

geneAREG, SDGF, AREGB
nameAmphiregulin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AREG_HUMANP15514ENSG00000109321374Hs.270833104640

Functions and classifications

GOC:cell surface, C:extracellular space, C:integral component of membrane, F:growth factor activity, P:cell proliferation, P:cell-cell signaling, P:epidermal growth factor receptor signaling pathway, P:G-protein coupled receptor signaling pathway, P:positive regulation of DNA replication, C:integral to membrane, C:cell surface, C:extracellular space, C:integral component of membrane, F:growth factor activity, P:cell proliferation, P:cell-cell signaling, P:epidermal growth factor receptor signaling pathway, P:G-protein coupled receptor signaling pathway, P:positive regulation of DNA replication, C:integral to membrane
UniProt3D-structure, Complete proteome, Cytokine, Direct protein sequencing, Disulfide bond, EGF-like domain, Glycoprotein, Growth factor, Membrane, Polymorphism, Reference proteome, Signal, Transmembrane, Transmembrane helix
PADBSIG: signalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp25141849aCanis lupus familiaris11bloodserumDHF (Dyssynchronous heart failure (DHF))3.610<0.05LC-MS/MS25141849
Exp25141849bCanis lupus familiaris12bloodserumCRT (Cardiac resynchronization therapy (CRT))1.020<0.05LC-MS/MS25141849
Exp26690514Homo sapiens24bloodwholeCAD (Coronary artery disease (CAD)) 1.45E-02Gene-array26690514
Exp26690514Homo sapiens24bloodwholeCAD (Coronary artery disease (CAD)) 3.06E-02Gene-array26690514
Exp26690514Homo sapiens24bloodwholeCAD (Coronary artery disease (CAD)) 3.27E-02Gene-array26690514

Compile date 02-09-2018© C/VD project