cvd-logocvd - Molecule ID A4558

geneADIPOQ, ACDC, ACRP30
nameAdiponectin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADIPO_HUMANQ15848ENSG000001810929370Hs.80485125853, 605441, 612556

Functions and classifications

GOC:cell surface, C:collagen, C:endoplasmic reticulum, C:extracellular space, F:cytokine activity, F:hormone activity, F:identical protein binding, F:sialic acid binding, P:adiponectin-activated signaling pathway, P:brown fat cell differentiation, P:cellular response to cAMP, P:cellular response to drug, P:cellular response to epinephrine stimulus, P:cellular response to insulin stimulus, P:circadian rhythm, P:detection of oxidative stress, P:fatty acid beta-oxidation, P:generation of precursor metabolites and energy, P:glucose homeostasis, P:glucose metabolic process, P:low-density lipoprotein particle clearance, P:membrane depolarization, P:membrane hyperpolarization, P:negative regulation of blood pressure, P:negative regulation of DNA biosynthetic process, P:negative regulation of ERK1 and ERK2 cascade, P:negative regulation of fat cell differentiation, P:negative regulation of gluconeogenesis, P:negative regulation of granulocyte differentiation, P:negative regulation of heterotypic cell-cell adhesion, P:negative regulation of hormone secretion, P:negative regulation of I-kappaB kinase/NF-kappaB signaling, P:negative regulation of inflammatory response, P:negative regulation of intracellular protein transport, P:negative regulation of low-density lipoprotein particle receptor biosynthetic process, P:negative regulation of macrophage derived foam cell differentiation, P:negative regulation of macrophage differentiation, P:negative regulation of MAP kinase activity, P:negative regulation of metanephric mesenchymal cell migration, P:negative regulation of phagocytosis, P:negative regulation of platelet-derived growth factor receptor-alpha signaling pathway, P:negative regulation of protein autophosphorylation, P:negative regulation of receptor binding, P:negative regulation of smooth muscle cell migration, P:negative regulation of smooth muscle cell proliferation, P:negative regulation of synaptic transmission, P:negative regulation of transcription, DNA-templated, P:negative regulation of tumor necrosis factor production, P:negative regulation of tumor necrosis factor-mediated signaling pathway, P:positive regulation of blood pressure, P:positive regulation of cAMP-dependent protein kinase activity, P:positive regulation of cholesterol efflux, P:positive regulation of fatty acid metabolic process, P:positive regulation of glucose import, P:positive regulation of glycogen (starch) synthase activity, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of interleukin-8 production, P:positive regulation of metanephric glomerular visceral epithelial cell development, P:positive regulation of monocyte chemotactic protein-1 production, P:positive regulation of myeloid cell apoptotic process, P:positive regulation of peptidyl-tyrosine phosphorylation, P:positive regulation of protein kinase A signaling, P:positive regulation of renal albumin absorption, P:protein heterotrimerization, P:protein homooligomerization, P:protein localization to plasma membrane, P:response to activity, P:response to ethanol, P:response to glucocorticoid, P:response to glucose, P:response to hypoxia, P:response to linoleic acid, P:response to nutrient, P:response to sucrose, P:response to tumor necrosis factor, C:collagen, P:response to sucrose, F:eukaryotic cell surface binding, P:adiponectin-mediated signaling pathway, P:negative regulation of eukaryotic cell surface binding, P:negative regulation of I-kappaB kinase/NF-kappaB cascade, P:negative regulation of transcription, DNA-dependent, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, P:positive regulation of protein kinase A signaling cascade, P:response to glucocorticoid stimulus, P:response to glucose stimulus, P:response to sucrose stimulus, P:positive regulation of protein kinase activity, P:response to drug, C:cell surface, C:collagen, C:endoplasmic reticulum, C:extracellular space, F:cytokine activity, F:hormone activity, F:identical protein binding, F:sialic acid binding, P:adiponectin-activated signaling pathway, P:brown fat cell differentiation, P:cellular response to cAMP, P:cellular response to drug, P:cellular response to epinephrine stimulus, P:cellular response to insulin stimulus, P:circadian rhythm, P:detection of oxidative stress, P:fatty acid beta-oxidation, P:generation of precursor metabolites and energy, P:glucose homeostasis, P:glucose metabolic process, P:low-density lipoprotein particle clearance, P:membrane depolarization, P:membrane hyperpolarization, P:negative regulation of blood pressure, P:negative regulation of DNA biosynthetic process, P:negative regulation of ERK1 and ERK2 cascade, P:negative regulation of fat cell differentiation, P:negative regulation of gluconeogenesis, P:negative regulation of granulocyte differentiation, P:negative regulation of heterotypic cell-cell adhesion, P:negative regulation of hormone secretion, P:negative regulation of I-kappaB kinase/NF-kappaB signaling, P:negative regulation of inflammatory response, P:negative regulation of intracellular protein transport, P:negative regulation of low-density lipoprotein particle receptor biosynthetic process, P:negative regulation of macrophage derived foam cell differentiation, P:negative regulation of macrophage differentiation, P:negative regulation of MAP kinase activity, P:negative regulation of metanephric mesenchymal cell migration, P:negative regulation of phagocytosis, P:negative regulation of platelet-derived growth factor receptor-alpha signaling pathway, P:negative regulation of protein autophosphorylation, P:negative regulation of receptor binding, P:negative regulation of smooth muscle cell migration, P:negative regulation of smooth muscle cell proliferation, P:negative regulation of synaptic transmission, P:negative regulation of transcription, DNA-templated, P:negative regulation of tumor necrosis factor production, P:negative regulation of tumor necrosis factor-mediated signaling pathway, P:positive regulation of blood pressure, P:positive regulation of cAMP-dependent protein kinase activity, P:positive regulation of cholesterol efflux, P:positive regulation of fatty acid metabolic process, P:positive regulation of glucose import, P:positive regulation of glycogen (starch) synthase activity, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of interleukin-8 production, P:positive regulation of metanephric glomerular visceral epithelial cell development, P:positive regulation of monocyte chemotactic protein-1 production, P:positive regulation of myeloid cell apoptotic process, P:positive regulation of peptidyl-tyrosine phosphorylation, P:positive regulation of protein kinase A signaling, P:positive regulation of renal albumin absorption, P:protein heterotrimerization, P:protein homooligomerization, P:protein localization to plasma membrane, P:response to activity, P:response to ethanol, P:response to glucocorticoid, P:response to glucose, P:response to hypoxia, P:response to linoleic acid, P:response to nutrient, P:response to sucrose, P:response to tumor necrosis factor, C:collagen, P:response to sucrose, F:eukaryotic cell surface binding, P:adiponectin-mediated signaling pathway, P:negative regulation of eukaryotic cell surface binding, P:negative regulation of I-kappaB kinase/NF-kappaB cascade, P:negative regulation of transcription, DNA-dependent, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, P:positive regulation of protein kinase A signaling cascade, P:response to glucocorticoid stimulus, P:response to glucose stimulus, P:response to sucrose stimulus, P:positive regulation of protein kinase activity, P:response to drug
UniProt3D-structure, Collagen, Complete proteome, Diabetes mellitus, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Hormone, Hydroxylation, Obesity, Pharmaceutical, Polymorphism, Reference proteome, Repeat, Secreted, Signal
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp27350024a1Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 1st set (113:117), triple vessel disease)0.683<0.05MALDI TOF/TOF27350024
Exp27350024a2Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 2nd set (114:118), triple vessel disease)1.226<0.05MALDI TOF/TOF27350024
Exp27350024a3Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 3rd set (115:119), triple vessel disease)0.949<0.05MALDI TOF/TOF27350024
Exp27350024bHomo sapiens40bloodplasmaCAD (Coronary artery disease (CAD) Verification Phase)0.7010.0025ELISA27350024
Exp27350024cHomo sapiens506bloodplasmaCAD (Coronary artery disease (CAD) Validation Phase)0.750<0.0001ELISA27350024

Compile date 02-09-2018© C/VD project