cvd-logocvd - Molecule ID A3582

geneACACA, ACAC, ACC1
nameAcetyl-CoA carboxylase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACACA_HUMANQ13085ENSG0000013214231Hs.160556200350, 613933

Functions and classifications

GOC:cell surface, C:mitochondrial nucleoid, C:mitochondrial proton-transporting ATP synthase, catalytic core, C:plasma membrane, F:ATP binding, F:MHC class I protein binding, F:proton-transporting ATP synthase activity, rotational mechanism, F:proton-transporting ATPase activity, rotational mechanism, P:angiogenesis, P:ATP hydrolysis coupled proton transport, P:lipid metabolic process, P:mitochondrial ATP synthesis coupled proton transport, P:negative regulation of cell adhesion involved in substrate-bound cell migration, P:regulation of intracellular pH, P:respiratory electron transport chain, C:proton-transporting two-sector ATPase complex, catalytic domain, P:ATP catabolic process, P:ATP synthesis coupled proton transport, C:mitochondrion, C:proton-transporting ATP synthase complex, catalytic core F(1), C:mitochondrial inner membrane, P:ATP synthesis coupled proton transport, P:negative regulation of cell adhesion involved in substrate-bound cell migration, F:ATP binding, F:calcium ion binding, F:eukaryotic cell surface binding, F:hydrogen ion transporting ATP synthase activity, rotational mechanism, F:hydrogen-exporting ATPase activity, phosphorylative mechanism, F:lipoprotein particle receptor activity, P:ADP biosynthetic process, C:proton-transporting ATP synthase complex, catalytic core F(1), C:mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)
UniProt3D-structure, Acetylation, Allosteric enzyme, Alternative promoter usage, ATP-binding, Biotin, Complete proteome, Cytoplasm, Direct protein sequencing, Fatty acid biosynthesis, Fatty acid metabolism, Ligase, Lipid biosynthesis, Lipid metabolism, Manganese, Metal-binding, Multifunctional enzyme, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)0.663<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.782<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)1.780<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))1.780<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.405<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.610<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))1.262<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.000<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project