cvd-logocvd - Molecule ID A2341

geneACTN1
nameAlpha-actinin 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACTN1_HUMANP12814ENSG0000007211087Hs.509765102575, 615193

Functions and classifications

GOC:cytoskeleton, C:cytosol, C:dendritic spine, C:extracellular vesicular exosome, C:fascia adherens, C:focal adhesion, C:nucleus, C:plasma membrane, C:platelet alpha granule lumen, C:pseudopodium, C:ruffle, C:Z disc, F:calcium ion binding, F:double-stranded RNA binding, F:integrin binding, P:actin filament bundle assembly, P:extracellular matrix organization, P:focal adhesion assembly, P:negative regulation of cellular component movement, P:platelet activation, P:platelet degranulation, P:regulation of apoptotic process, C:cortical actin cytoskeleton, C:stress fiber, P:actin crosslink formation, C:cytoskeleton, C:cytosol, C:dendritic spine, C:extracellular vesicular exosome, C:fascia adherens, C:focal adhesion, C:nucleus, C:plasma membrane, C:platelet alpha granule lumen, C:pseudopodium, C:ruffle, C:Z disc, F:calcium ion binding, F:double-stranded RNA binding, F:integrin binding, P:actin filament bundle assembly, P:extracellular matrix organization, P:focal adhesion assembly, P:negative regulation of cellular component movement, P:platelet activation, P:platelet degranulation, P:regulation of apoptotic process, C:cortical actin cytoskeleton, C:stress fiber, P:actin crosslink formation
UniProt3D-structure, Acetylation, Actin-binding, Alternative splicing, Calcium, Cell junction, Cell membrane, Cell projection, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Disease mutation, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21417265Homo sapiens17heartmyocardiumDCM (Dilated cardiomyopathy)2.0005.72E-10LC-MS/MS21417265
Exp27234505Homo sapiens35bloodplasmaMI (Myocardial Ischemic Injury)1.461<0.05LC-MS/MS27234505

Compile date 02-09-2018© C/VD project