cvd-logocvd - Molecule ID A2136

geneFZR1, CDH1, FYR
nameFizzy-related protein homolog
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
FZR_HUMANQ9UM11ENSG0000010532551343Hs.413133603619

Functions and classifications

GOC:cytosol, C:nuclear membrane, C:nucleoplasm, P:activation of anaphase-promoting complex activity, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:DNA repair, P:G2 DNA damage checkpoint, P:lens fiber cell differentiation, P:mitosis, P:negative regulation of cell aging, P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:positive regulation of cell proliferation, P:positive regulation of protein catabolic process, P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:protein K11-linked ubiquitination, P:regulation of meiosis, P:cell division, P:G2/M transition DNA damage checkpoint, P:S phase of mitotic cell cycle
UniProtAlternative splicing, Cell cycle, Cell division, Complete proteome, Cytoplasm, DNA damage, DNA repair, Mitosis, Nucleus, Phosphoprotein, Reference proteome, Repeat, Ubl conjugation pathway, WD repeat
PADBCC: cell cycle (turnover, mitosis, meiosis)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)0.508<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.824<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)0.855<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))0.855<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.658<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.319<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))1.551<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.075<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project