cvd-logocvd - Molecule ID A2047

geneSMARCA2, BAF190B, BRM
namePossible global transcription activator SNF2L2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
SMCA2_HUMANP51531ENSG000000805036595Hs.298990600014, 601358

Functions and classifications

GOC:intermediate filament cytoskeleton, C:nBAF complex, C:npBAF complex, C:nuclear chromatin, C:nucleoplasm, C:SWI/SNF complex, C:WINAC complex, F:ATP binding, F:DNA-dependent ATPase activity, F:helicase activity, F:RNA polymerase II transcription coactivator activity, F:transcription regulatory region DNA binding, P:aortic smooth muscle cell differentiation, P:chromatin remodeling, P:negative regulation of cell growth, P:negative regulation of cell proliferation, P:negative regulation of transcription from RNA polymerase II promoter, P:nervous system development, F:DNA binding, P:metabolic process, C:nBAF complex, F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, P:regulation of transcription, DNA-templated, C:intermediate filament cytoskeleton, C:nucleus, P:regulation of transcription, DNA-dependent, C:intermediate filament cytoskeleton, C:nBAF complex, C:npBAF complex, C:nuclear chromatin, C:nucleoplasm, C:SWI/SNF complex, C:WINAC complex, F:ATP binding, F:DNA-dependent ATPase activity, F:helicase activity, F:RNA polymerase II transcription coactivator activity, F:transcription regulatory region DNA binding, P:aortic smooth muscle cell differentiation, P:chromatin remodeling, P:negative regulation of cell growth, P:negative regulation of cell proliferation, P:negative regulation of transcription from RNA polymerase II promoter, P:nervous system development, F:DNA binding, P:metabolic process, C:nBAF complex, F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides, P:regulation of transcription, DNA-templated, C:intermediate filament cytoskeleton, C:nucleus, P:regulation of transcription, DNA-dependent
UniProt3D-structure, Acetylation, Activator, Alternative splicing, ATP-binding, Bromodomain, Complete proteome, Disease mutation, DNA-binding, Helicase, Hydrolase, Hypotrichosis, Mental retardation, Neurogenesis, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Transcription, Transcription regulation
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15769906aHomo sapiens19heartmyocardiumNICM (Pre-LVAD, nonischemic cardiomyopathy) 3.31E-07Gene-array15769906
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.112<0.05Gene-array19059264
Exp19336532bHomo sapiens24bloodmononuclear cellsNICM (Non-ischemic dilated cardiomyopathy (NIDCM) ) 0.0043056Gene-array19336532
Exp21173733Homo sapiens10bloodwholeAtherosclerosis (Atherosclerosis familial hypercholesterolemia) 0.006043Gene-array21173733
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.783<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)1.163<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))1.163<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.440<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.814<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))0.749<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.074<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project