cvd-logocvd - Molecule ID A1809

geneAPOC2, APC2
nameApolipoprotein C-II precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOC2_HUMANP02655ENSG00000234906344Hs.75615207750, 608083

Functions and classifications

GOC:chylomicron, C:early endosome, C:intermediate-density lipoprotein particle, C:low-density lipoprotein particle, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:lipase inhibitor activity, F:lipid binding, F:lipoprotein lipase activator activity, F:phospholipase activator activity, F:protein homodimerization activity, P:cholesterol efflux, P:cholesterol homeostasis, P:chylomicron remnant clearance, P:chylomicron remodeling, P:high-density lipoprotein particle clearance, P:lipid catabolic process, P:lipoprotein metabolic process, P:lipoprotein transport, P:negative regulation of cholesterol transport, P:negative regulation of lipid metabolic process, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of very-low-density lipoprotein particle clearance, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of fatty acid biosynthetic process, P:positive regulation of lipoprotein lipase activity, P:positive regulation of phospholipase activity, P:positive regulation of phospholipid catabolic process, P:positive regulation of triglyceride catabolic process, P:positive regulation of very-low-density lipoprotein particle remodeling, P:response to drug, P:retinoid metabolic process, P:reverse cholesterol transport, P:small molecule metabolic process, P:triglyceride homeostasis, P:very-low-density lipoprotein particle remodeling, F:enzyme activator activity, P:lipid metabolic process, P:lipid transport, P:positive regulation of catalytic activity, C:chylomicron, C:early endosome, C:intermediate-density lipoprotein particle, C:low-density lipoprotein particle, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:lipase inhibitor activity, F:lipid binding, F:lipoprotein lipase activator activity, F:phospholipase activator activity, F:protein homodimerization activity, P:cholesterol efflux, P:cholesterol homeostasis, P:chylomicron remnant clearance, P:chylomicron remodeling, P:high-density lipoprotein particle clearance, P:lipid catabolic process, P:lipoprotein metabolic process, P:lipoprotein transport, P:negative regulation of cholesterol transport, P:negative regulation of lipid metabolic process, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of very-low-density lipoprotein particle clearance, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of fatty acid biosynthetic process, P:positive regulation of lipoprotein lipase activity, P:positive regulation of phospholipase activity, P:positive regulation of phospholipid catabolic process, P:positive regulation of triglyceride catabolic process, P:positive regulation of very-low-density lipoprotein particle remodeling, P:response to drug, P:retinoid metabolic process, P:reverse cholesterol transport, P:small molecule metabolic process, P:triglyceride homeostasis, P:very-low-density lipoprotein particle remodeling, F:enzyme activator activity, P:lipid metabolic process, P:lipid transport, P:positive regulation of catalytic activity
UniProt3D-structure, Chylomicron, Complete proteome, Direct protein sequencing, Disease mutation, Hyperlipidemia, Lipid degradation, Lipid metabolism, Lipid transport, Polymorphism, Reference proteome, Secreted, Signal, Transport, VLDL
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21681990aMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.360<0.05MALDI-TOF/TOF21681990
Exp21681990bMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.310<0.05MALDI-TOF/TOF21681991
Exp21681990cMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.280<0.05ESI-LTQ(PQD)-Orbitrap21681991
Exp21681990dMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.250<0.05ESI-LTQ(PQD)-Orbitrap21681991
Exp27350024a3Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 3rd set (115:119), triple vessel disease)0.5240.0289MALDI TOF/TOF27350024
Exp27350024a5Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 5th set (115:117), double vessel disease)1.2620.02MALDI TOF/TOF27350024
Exp27350024bHomo sapiens40bloodplasmaCAD (Coronary artery disease (CAD) Verification Phase)1.6400.002ELISA27350024

Compile date 02-09-2018© C/VD project