cvd-logocvd - Molecule ID A1760

geneAML2, RUNX3, CBFA3
nameRUNT-related transcription factor 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
RUNX3_HUMANQ13761ENSG00000020633864Hs.170019600210

Functions and classifications

GOC:cytoplasm, C:nuclear chromatin, F:ATP binding, F:RNA polymerase II regulatory region sequence-specific DNA binding, F:sequence-specific DNA binding RNA polymerase II transcription factor activity, P:axon guidance, P:cell maturation, P:chondrocyte differentiation, P:hair follicle morphogenesis, P:interferon-gamma production, P:negative regulation of cell cycle, P:negative regulation of epithelial cell proliferation, P:negative regulation of transcription from RNA polymerase II promoter, P:peripheral nervous system neuron development, P:positive regulation of extrinsic apoptotic signaling pathway, P:protein phosphorylation, C:nucleus, F:DNA binding, F:sequence-specific DNA binding transcription factor activity, P:transcription, DNA-templated, P:regulation of transcription, DNA-templated, P:induction of apoptosis, C:nucleus, P:regulation of transcription, DNA-dependent, C:cytoplasm, C:nuclear chromatin, F:ATP binding, F:RNA polymerase II regulatory region sequence-specific DNA binding, F:sequence-specific DNA binding RNA polymerase II transcription factor activity, P:axon guidance, P:cell maturation, P:chondrocyte differentiation, P:hair follicle morphogenesis, P:interferon-gamma production, P:negative regulation of cell cycle, P:negative regulation of epithelial cell proliferation, P:negative regulation of transcription from RNA polymerase II promoter, P:peripheral nervous system neuron development, P:positive regulation of extrinsic apoptotic signaling pathway, P:protein phosphorylation, C:nucleus, F:DNA binding, F:sequence-specific DNA binding transcription factor activity, P:transcription, DNA-templated, P:regulation of transcription, DNA-templated, P:induction of apoptosis, C:nucleus, P:regulation of transcription, DNA-dependent
UniProtAlternative splicing, Complete proteome, Cytoplasm, DNA-binding, Nucleus, Phosphoprotein, Reference proteome, Transcription, Transcription regulation
PADBTF: transcription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseP-valueDetectionPubMed/DOI
Exp19336532bHomo sapiens24bloodmononuclear cellsNICM (Non-ischemic dilated cardiomyopathy (NIDCM) )0.0012964Gene-array19336532
Exp19336532bHomo sapiens24bloodmononuclear cellsNICM (Non-ischemic dilated cardiomyopathy (NIDCM) )0.0043876Gene-array19336532
Exp19336532cHomo sapiens24bloodmononuclear cellsICM (Ischemic cardiomyopathy (ICM))0.00865183Gene-array19336532
Exp19336532cHomo sapiens24bloodmononuclear cellsICM (Ischemic cardiomyopathy (ICM))0.02891365Gene-array19336532

Compile date 02-09-2018© C/VD project