cvd-logocvd - Molecule ID A1719

geneTGFBR2, Tbeta RIIC, TbetaRIIC
nameTGF-beta receptor type II precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
TGFR2_HUMANP37173ENSG000001635137048Hs.604277133239, 190182, 610168, 610380, 614331

Functions and classifications

GOC:caveola, C:cytosol, C:external side of plasma membrane, C:transforming growth factor beta receptor homodimeric complex, F:ATP binding, F:glycosaminoglycan binding, F:metal ion binding, F:receptor signaling protein serine/threonine kinase activity, F:SMAD binding, F:transforming growth factor beta binding, F:transforming growth factor beta receptor activity, type II, F:transforming growth factor beta-activated receptor activity, F:type I transforming growth factor beta receptor binding, F:type III transforming growth factor beta receptor binding, P:activation of protein kinase activity, P:aging, P:apoptotic process, P:brain development, P:bronchus morphogenesis, P:cartilage development, P:common-partner SMAD protein phosphorylation, P:digestive tract development, P:embryo implantation, P:embryonic cranial skeleton morphogenesis, P:embryonic hemopoiesis, P:gastrulation, P:heart development, P:in utero embryonic development, P:intracellular signal transduction, P:lens development in camera-type eye, P:lens fiber cell apoptotic process, P:lung lobe morphogenesis, P:mammary gland morphogenesis, P:myeloid dendritic cell differentiation, P:negative regulation of cardiac muscle cell proliferation, P:negative regulation of transforming growth factor beta receptor signaling pathway, P:organ regeneration, P:palate development, P:pathway-restricted SMAD protein phosphorylation, P:patterning of blood vessels, P:peptidyl-serine phosphorylation, P:peptidyl-threonine phosphorylation, P:positive regulation of B cell tolerance induction, P:positive regulation of epithelial cell migration, P:positive regulation of mesenchymal cell proliferation, P:positive regulation of NK T cell differentiation, P:positive regulation of reactive oxygen species metabolic process, P:positive regulation of skeletal muscle tissue regeneration, P:positive regulation of smooth muscle cell proliferation, P:positive regulation of T cell tolerance induction, P:positive regulation of tolerance induction to self antigen, P:receptor-mediated endocytosis, P:response to cholesterol, P:response to drug, P:response to estrogen, P:response to glucose, P:response to mechanical stimulus, P:response to nutrient, P:signal transduction by phosphorylation, P:smoothened signaling pathway, P:trachea formation, P:transforming growth factor beta receptor signaling pathway, P:vasculogenesis, P:wound healing, C:membrane, P:cell growth, P:signal transduction by phosphorylation, C:integral component of membrane, C:receptor complex, F:receptor activity, C:integral component of plasma membrane, C:integral component of membrane, P:transforming growth factor beta receptor signaling pathway, P:regulation of growth, P:vasculogenesis, C:integral to membrane, C:integral to membrane, C:external side of plasma membrane, F:protein serine/threonine kinase activity
UniProt3D-structure, Alternative splicing, Aortic aneurysm, Apoptosis, ATP-binding, Cell membrane, Complete proteome, Differentiation, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Growth regulation, Hereditary nonpolyposis colorectal cancer, Kinase, Magnesium, Manganese, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Serine/threonine-protein kinase, Signal, Transferase, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)0.556<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.735<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)1.116<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))1.116<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.306<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))2.585<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))1.456<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.085<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project