cvd-logocvd - Molecule ID A1714

geneAPOB
nameApolipoprotein B-100 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOB_HUMANP04114ENSG00000084674338Hs.120759107730, 144010, 615558

Functions and classifications

GOC:chylomicron remnant, C:clathrin-coated endocytic vesicle membrane, C:cytosol, C:early endosome, C:endocytic vesicle lumen, C:endoplasmic reticulum lumen, C:endoplasmic reticulum membrane, C:endosome lumen, C:endosome membrane, C:intermediate-density lipoprotein particle, C:low-density lipoprotein particle, C:mature chylomicron, C:plasma membrane, C:very-low-density lipoprotein particle, F:cholesterol transporter activity, F:heparin binding, F:low-density lipoprotein particle receptor binding, F:phospholipid binding, P:artery morphogenesis, P:blood coagulation, P:cellular response to prostaglandin stimulus, P:cellular response to tumor necrosis factor, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:fertilization, P:in utero embryonic development, P:leukocyte migration, P:lipoprotein biosynthetic process, P:lipoprotein catabolic process, P:lipoprotein metabolic process, P:lipoprotein transport, P:low-density lipoprotein particle clearance, P:low-density lipoprotein particle remodeling, P:nervous system development, P:phototransduction, visible light, P:positive regulation of cholesterol storage, P:positive regulation of macrophage derived foam cell differentiation, P:post-embryonic development, P:receptor-mediated endocytosis, P:regulation of cholesterol biosynthetic process, P:response to carbohydrate, P:response to lipopolysaccharide, P:response to selenium ion, P:response to virus, P:retinoid metabolic process, P:sperm motility, P:spermatogenesis, P:triglyceride catabolic process, P:triglyceride mobilization, P:very-low-density lipoprotein particle assembly, F:lipid transporter activity, C:endoplasmic reticulum, C:vesicle lumen, C:vesicle membrane, F:lipid binding, P:response to carbohydrate stimulus, P:cholesterol transport, C:chylomicron remnant, C:clathrin-coated endocytic vesicle membrane, C:cytosol, C:early endosome, C:endocytic vesicle lumen, C:endoplasmic reticulum lumen, C:endoplasmic reticulum membrane, C:endosome lumen, C:endosome membrane, C:intermediate-density lipoprotein particle, C:low-density lipoprotein particle, C:mature chylomicron, C:plasma membrane, C:very-low-density lipoprotein particle, F:cholesterol transporter activity, F:heparin binding, F:low-density lipoprotein particle receptor binding, F:phospholipid binding, P:artery morphogenesis, P:blood coagulation, P:cellular response to prostaglandin stimulus, P:cellular response to tumor necrosis factor, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:fertilization, P:in utero embryonic development, P:leukocyte migration, P:lipoprotein biosynthetic process, P:lipoprotein catabolic process, P:lipoprotein metabolic process, P:lipoprotein transport, P:low-density lipoprotein particle clearance, P:low-density lipoprotein particle remodeling, P:nervous system development, P:phototransduction, visible light, P:positive regulation of cholesterol storage, P:positive regulation of macrophage derived foam cell differentiation, P:post-embryonic development, P:receptor-mediated endocytosis, P:regulation of cholesterol biosynthetic process, P:response to carbohydrate, P:response to lipopolysaccharide, P:response to selenium ion, P:response to virus, P:retinoid metabolic process, P:sperm motility, P:spermatogenesis, P:triglyceride catabolic process, P:triglyceride mobilization, P:very-low-density lipoprotein particle assembly, F:lipid transporter activity, C:endoplasmic reticulum, C:vesicle lumen, C:vesicle membrane, F:lipid binding, P:response to carbohydrate stimulus, P:cholesterol transport
UniProtAcetylation, Atherosclerosis, Cholesterol metabolism, Chylomicron, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Heparin-binding, LDL, Lipid metabolism, Lipid transport, Lipoprotein, Palmitate, Polymorphism, Reference proteome, RNA editing, Secreted, Signal, Steroid metabolism, Sterol metabolism, Transport, VLDL
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21681990cMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)2.700<0.05ESI-LTQ(PQD)-Orbitrap21681991
Exp21681990dMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)2.100<0.05ESI-LTQ(PQD)-Orbitrap21681991
Exp23216991Homo sapiens354bloodserumCAD (Coronary artery disease (CAD))1.100<0.005Searchlight Protein Array System23216991
Exp27234505Homo sapiens35bloodplasmaMI (Myocardial Ischemic Injury)1.242<0.05LC-MS/MS27234505
Exp27350024a1Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 1st set (113:117), triple vessel disease)0.791<0.0001MALDI TOF/TOF27350024
Exp27350024a2Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 2nd set (114:118), triple vessel disease)0.8080.0003MALDI TOF/TOF27350024
Exp27350024a3Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 3rd set (115:119), triple vessel disease)0.7440.0139MALDI TOF/TOF27350024
Exp27350024a4Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 4th set (114:116), double vessel disease)0.7870.0123MALDI TOF/TOF27350024
Exp27350024a5Homo sapienspool; 2bloodplasmaCAD (Coronary artery disease (CAD) Discovery Phase, 5th set (115:117), double vessel disease)0.8870.0024MALDI TOF/TOF27350024
Exp27350024bHomo sapiens40bloodplasmaCAD (Coronary artery disease (CAD) Verification Phase)0.590<0.0001ELISA27350024

Compile date 02-09-2018© C/VD project