cvd-logocvd - Molecule ID A1625

geneC8A
nameComplement component C8 alpha chain precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CO8A_HUMANP07357ENSG00000157131731Hs.93210120950, 613790

Functions and classifications

GOC:extracellular space, C:membrane attack complex, P:complement activation, P:complement activation, alternative pathway, P:complement activation, classical pathway, P:cytolysis, P:innate immune response, P:regulation of complement activation, P:immune response, P:innate immune response, C:extracellular space, C:membrane attack complex, P:complement activation, P:complement activation, alternative pathway, P:complement activation, classical pathway, P:cytolysis, P:innate immune response, P:regulation of complement activation, P:immune response, P:innate immune response
UniProt3D-structure, Cell membrane, Cleavage on pair of basic residues, Complement alternate pathway, Complement pathway, Complete proteome, Cytolysis, Direct protein sequencing, Disulfide bond, EGF-like domain, Glycoprotein, Immunity, Innate immunity, Membrane, Membrane attack complex, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Transmembrane, Transmembrane beta strand
PADBTM: transmembrane

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21681990bMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)1.700<0.05MALDI-TOF/TOF21681991
Exp27234505Homo sapiens35bloodplasmaMI (Myocardial Ischemic Injury)1.596<0.05LC-MS/MS27234505

Compile date 02-09-2018© C/VD project