cvd-logocvd - Molecule ID A1609

geneCALR, CRTC
nameCalreticulin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CALR_HUMANP27797ENSG00000179218811Hs.515162109091

Functions and classifications

GOC:acrosomal vesicle, C:cell surface, C:cytosol, C:endocytic vesicle lumen, C:endoplasmic reticulum lumen, C:external side of plasma membrane, C:extracellular space, C:Golgi apparatus, C:integral component of lumenal side of endoplasmic reticulum membrane, C:MHC class I peptide loading complex, C:nucleus, C:perinuclear region of cytoplasm, C:polysome, C:proteinaceous extracellular matrix, C:sarcoplasmic reticulum lumen, F:androgen receptor binding, F:calcium ion binding, F:carbohydrate binding, F:chaperone binding, F:complement component C1q binding, F:DNA binding, F:hormone binding, F:iron ion binding, F:mRNA binding, F:peptide binding, F:protein binding involved in protein folding, F:unfolded protein binding, F:zinc ion binding, P:activation of signaling protein activity involved in unfolded protein response, P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, P:cardiac muscle cell differentiation, P:cell cycle arrest, P:cellular response to lithium ion, P:cellular senescence, P:chaperone-mediated protein folding, P:cortical actin cytoskeleton organization, P:glucocorticoid receptor signaling pathway, P:negative regulation of intracellular steroid hormone receptor signaling pathway, P:negative regulation of neuron differentiation, P:negative regulation of retinoic acid receptor signaling pathway, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of translation, P:peptide antigen assembly with MHC class I protein complex, P:positive regulation of cell cycle, P:positive regulation of cell proliferation, P:positive regulation of dendritic cell chemotaxis, P:positive regulation of DNA replication, P:positive regulation of gene expression, P:positive regulation of phagocytosis, P:positive regulation of substrate adhesion-dependent cell spreading, P:post-translational protein modification, P:protein export from nucleus, P:protein localization to nucleus, P:protein maturation by protein folding, P:protein N-linked glycosylation via asparagine, P:protein stabilization, P:regulation of apoptotic process, P:regulation of meiosis, P:response to drug, P:response to estradiol, P:response to testosterone, P:sequestering of calcium ion, P:spermatogenesis, C:extracellular matrix, C:sarcoplasmic reticulum, P:cellular response to organic substance, C:endoplasmic reticulum, P:protein folding, C:integral to lumenal side of endoplasmic reticulum membrane, P:response to estradiol stimulus, P:response to testosterone stimulus, C:acrosomal vesicle, C:cell surface, C:cytosol, C:endocytic vesicle lumen, C:endoplasmic reticulum lumen, C:external side of plasma membrane, C:extracellular space, C:Golgi apparatus, C:integral component of lumenal side of endoplasmic reticulum membrane, C:MHC class I peptide loading complex, C:nucleus, C:perinuclear region of cytoplasm, C:polysome, C:proteinaceous extracellular matrix, C:sarcoplasmic reticulum lumen, F:androgen receptor binding, F:calcium ion binding, F:carbohydrate binding, F:chaperone binding, F:complement component C1q binding, F:DNA binding, F:hormone binding, F:iron ion binding, F:mRNA binding, F:peptide binding, F:protein binding involved in protein folding, F:unfolded protein binding, F:zinc ion binding, P:activation of signaling protein activity involved in unfolded protein response, P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, P:cardiac muscle cell differentiation, P:cell cycle arrest, P:cellular response to lithium ion, P:cellular senescence, P:chaperone-mediated protein folding, P:cortical actin cytoskeleton organization, P:glucocorticoid receptor signaling pathway, P:negative regulation of intracellular steroid hormone receptor signaling pathway, P:negative regulation of neuron differentiation, P:negative regulation of retinoic acid receptor signaling pathway, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of translation, P:peptide antigen assembly with MHC class I protein complex, P:positive regulation of cell cycle, P:positive regulation of cell proliferation, P:positive regulation of dendritic cell chemotaxis, P:positive regulation of DNA replication, P:positive regulation of gene expression, P:positive regulation of phagocytosis, P:positive regulation of substrate adhesion-dependent cell spreading, P:post-translational protein modification, P:protein export from nucleus, P:protein localization to nucleus, P:protein maturation by protein folding, P:protein N-linked glycosylation via asparagine, P:protein stabilization, P:regulation of apoptotic process, P:regulation of meiosis, P:response to drug, P:response to estradiol, P:response to testosterone, P:sequestering of calcium ion, P:spermatogenesis, C:extracellular matrix, C:sarcoplasmic reticulum, P:cellular response to organic substance, C:endoplasmic reticulum, P:protein folding, C:integral to lumenal side of endoplasmic reticulum membrane, P:response to estradiol stimulus, P:response to testosterone stimulus
UniProt3D-structure, Acetylation, Calcium, Chaperone, Complete proteome, Cytoplasm, Direct protein sequencing, Disulfide bond, Endoplasmic reticulum, Extracellular matrix, Glycoprotein, Lectin, Metal-binding, Reference proteome, Repeat, Sarcoplasmic reticulum, Secreted, Signal, Zinc
PADBCHA: chaperone, chaperonin

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17106732Homo sapiens12heartendocardiumDCMi (Inflammatory dilated cardiomyopathy (DCMi)) 5.27E-04Gene-array17106732
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.202<0.05Gene-array19059264
Exp21417265Homo sapiens17heartmyocardiumDCM (Dilated cardiomyopathy)2.0001.44E-12LC-MS/MS21417265
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.618<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)1.142<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))1.142<0.05Gene-array21868699
Exp22276806Homo sapiens16aortavalvesStenosis (Aortic stenosis)-1.6280.01925MALDI-TOF/TOF22276806
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.258<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))1.621<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))0.488<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.119<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project