cvd-logocvd - Molecule ID A1552

geneAPOA1, A175P
nameApolipoprotein A-I precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOA1_HUMANP02647ENSG00000118137335Hs.93194105200, 107680, 205400, 604091

Functions and classifications

GOC:cytosol, C:early endosome, C:endocytic vesicle lumen, C:endoplasmic reticulum lumen, C:nucleus, C:plasma membrane, C:secretory granule lumen, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:beta-amyloid binding, F:cholesterol binding, F:cholesterol transporter activity, F:high-density lipoprotein particle binding, F:lipase inhibitor activity, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:phospholipid binding, F:phospholipid transporter activity, P:adrenal gland development, P:blood vessel endothelial cell migration, P:cholesterol biosynthetic process, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol import, P:cholesterol metabolic process, P:endothelial cell proliferation, P:G-protein coupled receptor signaling pathway, P:glucocorticoid metabolic process, P:high-density lipoprotein particle assembly, P:high-density lipoprotein particle clearance, P:high-density lipoprotein particle remodeling, P:lipid storage, P:lipoprotein biosynthetic process, P:lipoprotein metabolic process, P:negative regulation of cell adhesion molecule production, P:negative regulation of cytokine secretion involved in immune response, P:negative regulation of heterotypic cell-cell adhesion, P:negative regulation of inflammatory response, P:negative regulation of interleukin-1 beta secretion, P:negative regulation of lipase activity, P:negative regulation of tumor necrosis factor-mediated signaling pathway, P:negative regulation of very-low-density lipoprotein particle remodeling, P:organ regeneration, P:peptidyl-methionine modification, P:peripheral nervous system axon regeneration, P:phosphatidylcholine biosynthetic process, P:phospholipid efflux, P:phospholipid homeostasis, P:phototransduction, visible light, P:platelet activation, P:platelet degranulation, P:positive regulation of cholesterol esterification, P:positive regulation of hydrolase activity, P:positive regulation of transferase activity, P:protein oxidation, P:protein stabilization, P:regulation of Cdc42 protein signal transduction, P:regulation of intestinal cholesterol absorption, P:regulation of protein phosphorylation, P:response to drug, P:response to estrogen, P:response to nutrient, P:retinoid metabolic process, P:reverse cholesterol transport, P:triglyceride homeostasis, C:extracellular region, F:lipid binding, P:lipid transport, C:endocytic vesicle, C:secretory granule, P:negative regulation of hydrolase activity, P:triglyceride homeostasis, C:cytosol, C:early endosome, C:endocytic vesicle lumen, C:endoplasmic reticulum lumen, C:nucleus, C:plasma membrane, C:secretory granule lumen, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:beta-amyloid binding, F:cholesterol binding, F:cholesterol transporter activity, F:high-density lipoprotein particle binding, F:lipase inhibitor activity, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:phospholipid binding, F:phospholipid transporter activity, P:adrenal gland development, P:blood vessel endothelial cell migration, P:cholesterol biosynthetic process, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol import, P:cholesterol metabolic process, P:endothelial cell proliferation, P:G-protein coupled receptor signaling pathway, P:glucocorticoid metabolic process, P:high-density lipoprotein particle assembly, P:high-density lipoprotein particle clearance, P:high-density lipoprotein particle remodeling, P:lipid storage, P:lipoprotein biosynthetic process, P:lipoprotein metabolic process, P:negative regulation of cell adhesion molecule production, P:negative regulation of cytokine secretion involved in immune response, P:negative regulation of heterotypic cell-cell adhesion, P:negative regulation of inflammatory response, P:negative regulation of interleukin-1 beta secretion, P:negative regulation of lipase activity, P:negative regulation of tumor necrosis factor-mediated signaling pathway, P:negative regulation of very-low-density lipoprotein particle remodeling, P:organ regeneration, P:peptidyl-methionine modification, P:peripheral nervous system axon regeneration, P:phosphatidylcholine biosynthetic process, P:phospholipid efflux, P:phospholipid homeostasis, P:phototransduction, visible light, P:platelet activation, P:platelet degranulation, P:positive regulation of cholesterol esterification, P:positive regulation of hydrolase activity, P:positive regulation of transferase activity, P:protein oxidation, P:protein stabilization, P:regulation of Cdc42 protein signal transduction, P:regulation of intestinal cholesterol absorption, P:regulation of protein phosphorylation, P:response to drug, P:response to estrogen, P:response to nutrient, P:retinoid metabolic process, P:reverse cholesterol transport, P:triglyceride homeostasis, C:extracellular region, F:lipid binding, P:lipid transport, C:endocytic vesicle, C:secretory granule, P:negative regulation of hydrolase activity, P:triglyceride homeostasis
UniProt3D-structure, Amyloid, Amyloidosis, Atherosclerosis, Cholesterol metabolism, Complete proteome, Direct protein sequencing, Disease mutation, Glycation, Glycoprotein, HDL, Lipid metabolism, Lipid transport, Lipoprotein, Neuropathy, Oxidation, Palmitate, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Steroid metabolism, Sterol metabolism, Transport
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21681990aMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.370<0.05MALDI-TOF/TOF21681990
Exp21681990bMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.310<0.05MALDI-TOF/TOF21681991
Exp21681990cMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.390<0.05ESI-LTQ(PQD)-Orbitrap21681991
Exp21681990dMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.320<0.05ESI-LTQ(PQD)-Orbitrap21681991
Exp22276806Homo sapiens16aortavalvesStenosis (Aortic stenosis)1.6210.007406MALDI-TOF/TOF22276806
Exp22276806Homo sapiens16aortavalvesStenosis (Aortic stenosis)2.5130.02304MALDI-TOF/TOF22276806
Exp22276806Homo sapiens16aortavalvesStenosis (Aortic stenosis)2.5870.005885MALDI-TOF/TOF22276806
Exp23216991Homo sapiens354bloodserumCAD (Coronary artery disease (CAD))0.520<0.001Searchlight Protein Array System23216991
Exp24859250Homo sapiens20bloodplasmaCHD (Coronary heart disease (CHD))0.6390.002811nanoLC-MS/MS24859250

Compile date 02-09-2018© C/VD project