cvd-logocvd - Molecule ID A1491

geneCOL1A1
nameCollagen alpha-1(I) chain
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CO1A1_HUMANP02452ENSG000001088211277Hs.172928114000, 120150, 130000, 130060, 166200, 166210, 166220, 166710, 259420, 607907

Functions and classifications

GOC:collagen type I, C:endoplasmic reticulum lumen, C:extracellular space, F:extracellular matrix structural constituent, F:identical protein binding, F:metal ion binding, F:platelet-derived growth factor binding, P:blood vessel development, P:bone trabecula formation, P:cartilage development involved in endochondral bone morphogenesis, P:cellular response to amino acid stimulus, P:cellular response to mechanical stimulus, P:cellular response to retinoic acid, P:cellular response to transforming growth factor beta stimulus, P:collagen biosynthetic process, P:collagen catabolic process, P:collagen fibril organization, P:embryonic skeletal system development, P:endochondral ossification, P:extracellular matrix disassembly, P:face morphogenesis, P:intramembranous ossification, P:leukocyte migration, P:negative regulation of cell-substrate adhesion, P:osteoblast differentiation, P:platelet activation, P:positive regulation of canonical Wnt signaling pathway, P:positive regulation of cell migration, P:positive regulation of epithelial to mesenchymal transition, P:positive regulation of transcription, DNA-templated, P:protein heterotrimerization, P:protein localization to nucleus, P:protein transport, P:response to cAMP, P:response to corticosteroid, P:response to estradiol, P:response to hydrogen peroxide, P:response to nutrient, P:response to peptide hormone, P:sensory perception of sound, P:skin morphogenesis, P:tooth mineralization, P:visual perception, P:cell adhesion, C:collagen, C:cytoplasm, P:skin development, P:wound healing, P:axon guidance, P:cellular response to growth factor stimulus, P:positive regulation of canonical Wnt receptor signaling pathway, P:positive regulation of transcription, DNA-dependent, P:response to corticosteroid stimulus, P:response to inorganic substance, P:response to peptide hormone stimulus, C:collagen type I, C:endoplasmic reticulum lumen, C:extracellular space, F:extracellular matrix structural constituent, F:identical protein binding, F:metal ion binding, F:platelet-derived growth factor binding, P:blood vessel development, P:bone trabecula formation, P:cartilage development involved in endochondral bone morphogenesis, P:cellular response to amino acid stimulus, P:cellular response to mechanical stimulus, P:cellular response to retinoic acid, P:cellular response to transforming growth factor beta stimulus, P:collagen biosynthetic process, P:collagen catabolic process, P:collagen fibril organization, P:embryonic skeletal system development, P:endochondral ossification, P:extracellular matrix disassembly, P:face morphogenesis, P:intramembranous ossification, P:leukocyte migration, P:negative regulation of cell-substrate adhesion, P:osteoblast differentiation, P:platelet activation, P:positive regulation of canonical Wnt signaling pathway, P:positive regulation of cell migration, P:positive regulation of epithelial to mesenchymal transition, P:positive regulation of transcription, DNA-templated, P:protein heterotrimerization, P:protein localization to nucleus, P:protein transport, P:response to cAMP, P:response to corticosteroid, P:response to estradiol, P:response to hydrogen peroxide, P:response to nutrient, P:response to peptide hormone, P:sensory perception of sound, P:skin morphogenesis, P:tooth mineralization, P:visual perception, P:cell adhesion, C:collagen, C:cytoplasm, P:skin development, P:wound healing, P:axon guidance, P:cellular response to growth factor stimulus, P:positive regulation of canonical Wnt receptor signaling pathway, P:positive regulation of transcription, DNA-dependent, P:response to corticosteroid stimulus, P:response to inorganic substance, P:response to peptide hormone stimulus
UniProt3D-structure, Calcium, Chromosomal rearrangement, Collagen, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Dwarfism, Ehlers-Danlos syndrome, Extracellular matrix, Glycoprotein, Hydroxylation, Metal-binding, Osteogenesis imperfecta, Polymorphism, Pyrrolidone carboxylic acid, Reference proteome, Repeat, Secreted, Signal
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21417265Homo sapiens17heartmyocardiumDCM (Dilated cardiomyopathy)5.1000.003LC-MS/MS21417265
Exp21681990dMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.420<0.05ESI-LTQ(PQD)-Orbitrap21681991

Compile date 02-09-2018© C/VD project