cvd-logocvd - Molecule ID A1379

geneHMGB2, HMG2
nameHigh mobility group protein B2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
HMGB2_HUMANP26583ENSG000001641043148Hs.434953163906

Functions and classifications

GOC:condensed chromosome, C:extracellular space, C:nucleoplasm, C:perinuclear region of cytoplasm, C:protein complex, F:chemoattractant activity, F:damaged DNA binding, F:DNA binding, bending, F:double-stranded DNA binding, F:RAGE receptor binding, F:sequence-specific DNA binding transcription factor activity, F:single-stranded DNA binding, F:transcription regulatory region DNA binding, P:apoptotic DNA fragmentation, P:base-excision repair, DNA ligation, P:cell chemotaxis, P:cellular response to lipopolysaccharide, P:DNA topological change, P:male gonad development, P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, P:negative regulation of transcription, DNA-templated, P:nucleosome assembly, P:phosphatidylinositol-mediated signaling, P:positive regulation of DNA binding, P:positive regulation of endothelial cell proliferation, P:positive regulation of erythrocyte differentiation, P:positive regulation of megakaryocyte differentiation, P:positive regulation of nuclease activity, P:positive regulation of transcription from RNA polymerase II promoter, P:response to steroid hormone, P:spermatid nucleus differentiation, P:V(D)J recombination, C:nucleus, F:DNA binding, P:negative regulation of transcription, DNA-dependent, P:response to steroid hormone stimulus, C:condensed chromosome, C:extracellular space, C:nucleoplasm, C:perinuclear region of cytoplasm, C:protein complex, F:chemoattractant activity, F:damaged DNA binding, F:DNA binding, bending, F:double-stranded DNA binding, F:RAGE receptor binding, F:sequence-specific DNA binding transcription factor activity, F:single-stranded DNA binding, F:transcription regulatory region DNA binding, P:apoptotic DNA fragmentation, P:base-excision repair, DNA ligation, P:cell chemotaxis, P:cellular response to lipopolysaccharide, P:DNA topological change, P:male gonad development, P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, P:negative regulation of transcription, DNA-templated, P:nucleosome assembly, P:phosphatidylinositol-mediated signaling, P:positive regulation of DNA binding, P:positive regulation of endothelial cell proliferation, P:positive regulation of erythrocyte differentiation, P:positive regulation of megakaryocyte differentiation, P:positive regulation of nuclease activity, P:positive regulation of transcription from RNA polymerase II promoter, P:response to steroid hormone, P:spermatid nucleus differentiation, P:V(D)J recombination, C:nucleus, F:DNA binding, P:negative regulation of transcription, DNA-dependent, P:response to steroid hormone stimulus
UniProtAcetylation, Chromosome, Complete proteome, DNA-binding, Nucleus, Reference proteome, Repeat, Phosphoprotein
PADBTF: transcription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseP-valueDetectionPubMed/DOI
Exp19336532bHomo sapiens24bloodmononuclear cellsNICM (Non-ischemic dilated cardiomyopathy (NIDCM) )0.0022131Gene-array19336532
Exp24339868Homo sapiens17heartapex left ventricleDCM (Dilated cardiomyopathy (DCM))6.15E-05Gene-array24339868

Compile date 02-09-2018© C/VD project