cvd-logocvd - Molecule ID A1276

geneCLU, APOJ, CLI
nameClusterin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CLUS_HUMANP10909ENSG000001208851191Hs.436657185430

Functions and classifications

GOC:chromaffin granule, C:cytosol, C:endoplasmic reticulum, C:mitochondrial membrane, C:mitochondrion, C:nucleus, C:perinuclear region of cytoplasm, C:platelet alpha granule lumen, C:spherical high-density lipoprotein particle, F:misfolded protein binding, F:ubiquitin protein ligase binding, P:chaperone-mediated protein folding, P:complement activation, P:complement activation, classical pathway, P:innate immune response, P:intrinsic apoptotic signaling pathway, P:lipid metabolic process, P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, P:negative regulation of protein homooligomerization, P:platelet activation, P:platelet degranulation, P:positive regulation of apoptotic process, P:positive regulation of intrinsic apoptotic signaling pathway, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process, P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process, P:protein stabilization, P:release of cytochrome c from mitochondria, P:response to misfolded protein, P:response to virus, P:reverse cholesterol transport, P:cell death, C:aggresome, C:chromaffin granule, C:growth cone, P:cellular response to growth factor stimulus, P:endocrine pancreas development, P:negative regulation of apoptotic process, P:neuron projection morphogenesis, P:positive regulation of cell differentiation, P:positive regulation of cell proliferation, P:response to oxidative stress, C:aggresome, P:response to wounding, C:chromaffin granule, C:cytosol, C:endoplasmic reticulum, C:mitochondrial membrane, C:mitochondrion, C:nucleus, C:perinuclear region of cytoplasm, C:platelet alpha granule lumen, C:spherical high-density lipoprotein particle, F:misfolded protein binding, F:ubiquitin protein ligase binding, P:chaperone-mediated protein folding, P:complement activation, P:complement activation, classical pathway, P:innate immune response, P:intrinsic apoptotic signaling pathway, P:lipid metabolic process, P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, P:negative regulation of protein homooligomerization, P:platelet activation, P:platelet degranulation, P:positive regulation of apoptotic process, P:positive regulation of intrinsic apoptotic signaling pathway, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process, P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process, P:protein stabilization, P:release of cytochrome c from mitochondria, P:response to misfolded protein, P:response to virus, P:reverse cholesterol transport, P:cell death, C:aggresome, C:chromaffin granule, C:growth cone, P:cellular response to growth factor stimulus, P:endocrine pancreas development, P:negative regulation of apoptotic process, P:neuron projection morphogenesis, P:positive regulation of cell differentiation, P:positive regulation of cell proliferation, P:response to oxidative stress, C:aggresome, P:response to wounding
UniProtAlternative splicing, Apoptosis, Chaperone, Complement pathway, Complete proteome, Cytoplasm, Cytoplasmic vesicle, Direct protein sequencing, Disulfide bond, Endoplasmic reticulum, Glycoprotein, Immunity, Innate immunity, Membrane, Microsome, Mitochondrion, Nucleus, Polymorphism, Reference proteome, Secreted, Signal, Ubl conjugation, Lipoprotein
PADBCHA: chaperone, chaperonin

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21681990aMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.850<0.05MALDI-TOF/TOF21681990
Exp27234505Homo sapiens35bloodplasmaMI (Myocardial Ischemic Injury)0.638<0.05LC-MS/MS27234505

Compile date 02-09-2018© C/VD project