cvd-logocvd - Molecule ID A1176

geneAPOE
nameApolipoprotein E precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOE_HUMANP02649ENSG00000130203348Hs.654439104310, 107741, 143890, 269600, 611771

Functions and classifications

GOC:chylomicron, C:dendrite, C:early endosome, C:endocytic vesicle lumen, C:extrinsic component of external side of plasma membrane, C:Golgi apparatus, C:high-density lipoprotein particle, C:intermediate-density lipoprotein particle, C:late endosome, C:low-density lipoprotein particle, C:neuronal cell body, C:plasma membrane, C:very-low-density lipoprotein particle, F:antioxidant activity, F:beta-amyloid binding, F:cholesterol transporter activity, F:heparin binding, F:hydroxyapatite binding, F:lipid transporter activity, F:lipoprotein particle binding, F:low-density lipoprotein particle receptor binding, F:metal chelating activity, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:phospholipid binding, F:protein homodimerization activity, F:very-low-density lipoprotein particle receptor binding, P:aging, P:artery morphogenesis, P:cell death, P:cellular calcium ion homeostasis, P:cellular response to cholesterol, P:cellular response to growth factor stimulus, P:cellular response to interleukin-1, P:cGMP-mediated signaling, P:cholesterol catabolic process, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:chylomicron remnant clearance, P:cytoskeleton organization, P:G-protein coupled receptor signaling pathway, P:high-density lipoprotein particle assembly, P:high-density lipoprotein particle clearance, P:high-density lipoprotein particle remodeling, P:intracellular transport, P:lipoprotein biosynthetic process, P:lipoprotein catabolic process, P:lipoprotein metabolic process, P:low-density lipoprotein particle remodeling, P:maintenance of location in cell, P:negative regulation of blood vessel endothelial cell migration, P:negative regulation of cholesterol biosynthetic process, P:negative regulation of endothelial cell proliferation, P:negative regulation of inflammatory response, P:negative regulation of MAP kinase activity, P:negative regulation of neuron apoptotic process, P:negative regulation of platelet activation, P:nitric oxide mediated signal transduction, P:oligodendrocyte differentiation, P:peripheral nervous system axon regeneration, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of axon extension, P:positive regulation of cGMP biosynthetic process, P:positive regulation of cholesterol efflux, P:positive regulation of cholesterol esterification, P:positive regulation of low-density lipoprotein particle receptor catabolic process, P:positive regulation of membrane protein ectodomain proteolysis, P:positive regulation of nitric-oxide synthase activity, P:receptor-mediated endocytosis, P:regulation of axon extension, P:regulation of Cdc42 protein signal transduction, P:regulation of gene expression, P:regulation of neuronal synaptic plasticity, P:response to dietary excess, P:response to ethanol, P:response to insulin, P:response to reactive oxygen species, P:response to retinoic acid, P:retinoid metabolic process, P:reverse cholesterol transport, P:synaptic transmission, cholinergic, P:triglyceride metabolic process, P:vasodilation, P:very-low-density lipoprotein particle clearance, P:very-low-density lipoprotein particle remodeling, P:positive regulation of catalytic activity, P:response to oxidative stress, C:extracellular region, F:lipid binding, P:lipid transport, C:cytoplasm, C:extrinsic to external side of plasma membrane, C:microtubule, P:induction of apoptosis, P:negative regulation of apoptotic process, C:extracellular space, C:chylomicron, C:dendrite, C:early endosome, C:endocytic vesicle lumen, C:extrinsic component of external side of plasma membrane, C:Golgi apparatus, C:high-density lipoprotein particle, C:intermediate-density lipoprotein particle, C:late endosome, C:low-density lipoprotein particle, C:neuronal cell body, C:plasma membrane, C:very-low-density lipoprotein particle, F:antioxidant activity, F:beta-amyloid binding, F:cholesterol transporter activity, F:heparin binding, F:hydroxyapatite binding, F:lipid transporter activity, F:lipoprotein particle binding, F:low-density lipoprotein particle receptor binding, F:metal chelating activity, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:phospholipid binding, F:protein homodimerization activity, F:very-low-density lipoprotein particle receptor binding, P:aging, P:artery morphogenesis, P:cell death, P:cellular calcium ion homeostasis, P:cellular response to cholesterol, P:cellular response to growth factor stimulus, P:cellular response to interleukin-1, P:cGMP-mediated signaling, P:cholesterol catabolic process, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:chylomicron remnant clearance, P:cytoskeleton organization, P:G-protein coupled receptor signaling pathway, P:high-density lipoprotein particle assembly, P:high-density lipoprotein particle clearance, P:high-density lipoprotein particle remodeling, P:intracellular transport, P:lipoprotein biosynthetic process, P:lipoprotein catabolic process, P:lipoprotein metabolic process, P:low-density lipoprotein particle remodeling, P:maintenance of location in cell, P:negative regulation of blood vessel endothelial cell migration, P:negative regulation of cholesterol biosynthetic process, P:negative regulation of endothelial cell proliferation, P:negative regulation of inflammatory response, P:negative regulation of MAP kinase activity, P:negative regulation of neuron apoptotic process, P:negative regulation of platelet activation, P:nitric oxide mediated signal transduction, P:oligodendrocyte differentiation, P:peripheral nervous system axon regeneration, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of axon extension, P:positive regulation of cGMP biosynthetic process, P:positive regulation of cholesterol efflux, P:positive regulation of cholesterol esterification, P:positive regulation of low-density lipoprotein particle receptor catabolic process, P:positive regulation of membrane protein ectodomain proteolysis, P:positive regulation of nitric-oxide synthase activity, P:receptor-mediated endocytosis, P:regulation of axon extension, P:regulation of Cdc42 protein signal transduction, P:regulation of gene expression, P:regulation of neuronal synaptic plasticity, P:response to dietary excess, P:response to ethanol, P:response to insulin, P:response to reactive oxygen species, P:response to retinoic acid, P:retinoid metabolic process, P:reverse cholesterol transport, P:synaptic transmission, cholinergic, P:triglyceride metabolic process, P:vasodilation, P:very-low-density lipoprotein particle clearance, P:very-low-density lipoprotein particle remodeling, P:positive regulation of catalytic activity, P:response to oxidative stress, C:extracellular region, F:lipid binding, P:lipid transport, C:cytoplasm, C:extrinsic to external side of plasma membrane, C:microtubule, P:induction of apoptosis, P:negative regulation of apoptotic process, C:extracellular space
UniProt3D-structure, Alzheimer disease, Amyloidosis, Cholesterol metabolism, Chylomicron, Complete proteome, Direct protein sequencing, Disease mutation, Glycation, Glycoprotein, HDL, Heparin-binding, Hyperlipidemia, Lipid metabolism, Lipid transport, Neurodegeneration, Oxidation, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Steroid metabolism, Sterol metabolism, Transport, VLDL, Lipoprotein
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21681990aMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.120<0.05MALDI-TOF/TOF21681990
Exp21681990bMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.060<0.05MALDI-TOF/TOF21681991
Exp21681990cMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.090<0.05ESI-LTQ(PQD)-Orbitrap21681991
Exp21681990dMus musculus6bloodplasmaCAD (APOE-knock out Coronary artery disease (CAD) progression model)0.070<0.05ESI-LTQ(PQD)-Orbitrap21681991
Exp27234505Homo sapiens35bloodplasmaMI (Myocardial Ischemic Injury)2.436<0.05LC-MS/MS27234505

Compile date 02-09-2018© C/VD project