cvd-logocvd - Molecule ID A1169

geneAPP, A4, AD1
nameAmyloid beta A4 protein
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
A4_HUMANP05067ENSG00000142192351Hs.434980104300, 104760, 605714

Functions and classifications

GOC:apical part of cell, C:axon, C:cell surface, C:ciliary rootlet, C:coated pit, C:cytosol, C:dendritic shaft, C:dendritic spine, C:extracellular region, C:Golgi apparatus, C:integral component of plasma membrane, C:neuromuscular junction, C:perinuclear region of cytoplasm, C:platelet alpha granule lumen, C:spindle midzone, C:synapse, F:DNA binding, F:heparin binding, F:peptidase activator activity, F:serine-type endopeptidase inhibitor activity, F:transition metal ion binding, P:adult locomotory behavior, P:axon cargo transport, P:axon midline choice point recognition, P:cell adhesion, P:cellular copper ion homeostasis, P:cholesterol metabolic process, P:collateral sprouting in absence of injury, P:dendrite development, P:endocytosis, P:extracellular matrix organization, P:forebrain development, P:innate immune response, P:ionotropic glutamate receptor signaling pathway, P:mating behavior, P:mitotic G2 phase, P:mRNA polyadenylation, P:negative regulation of neuron differentiation, P:neuromuscular process controlling balance, P:neuron apoptotic process, P:neuron remodeling, P:Notch signaling pathway, P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway, P:platelet activation, P:platelet degranulation, P:positive regulation of G2/M transition of mitotic cell cycle, P:positive regulation of mitotic cell cycle, P:positive regulation of transcription from RNA polymerase II promoter, P:protein phosphorylation, P:regulation of epidermal growth factor-activated receptor activity, P:regulation of multicellular organism growth, P:regulation of protein binding, P:regulation of synapse structure and activity, P:regulation of translation, P:response to oxidative stress, P:smooth endoplasmic reticulum calcium ion homeostasis, P:suckling behavior, P:synaptic growth at neuromuscular junction, P:visual learning, C:integral component of membrane, C:cytoplasmic vesicle, C:plasma membrane, F:peptidase activity, P:negative regulation of endopeptidase activity, P:proteolysis, C:integral to plasma membrane, P:G2 phase of mitotic cell cycle, P:induction of apoptosis, C:integral to membrane, C:apical part of cell, C:axon, C:cell surface, C:ciliary rootlet, C:coated pit, C:cytosol, C:dendritic shaft, C:dendritic spine, C:extracellular region, C:Golgi apparatus, C:integral component of plasma membrane, C:neuromuscular junction, C:perinuclear region of cytoplasm, C:platelet alpha granule lumen, C:spindle midzone, C:synapse, F:DNA binding, F:heparin binding, F:peptidase activator activity, F:serine-type endopeptidase inhibitor activity, F:transition metal ion binding, P:adult locomotory behavior, P:axon cargo transport, P:axon midline choice point recognition, P:cell adhesion, P:cellular copper ion homeostasis, P:cholesterol metabolic process, P:collateral sprouting in absence of injury, P:dendrite development, P:endocytosis, P:extracellular matrix organization, P:forebrain development, P:innate immune response, P:ionotropic glutamate receptor signaling pathway, P:mating behavior, P:mitotic G2 phase, P:mRNA polyadenylation, P:negative regulation of neuron differentiation, P:neuromuscular process controlling balance, P:neuron apoptotic process, P:neuron remodeling, P:Notch signaling pathway, P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway, P:platelet activation, P:platelet degranulation, P:positive regulation of G2/M transition of mitotic cell cycle, P:positive regulation of mitotic cell cycle, P:positive regulation of transcription from RNA polymerase II promoter, P:protein phosphorylation, P:regulation of epidermal growth factor-activated receptor activity, P:regulation of multicellular organism growth, P:regulation of protein binding, P:regulation of synapse structure and activity, P:regulation of translation, P:response to oxidative stress, P:smooth endoplasmic reticulum calcium ion homeostasis, P:suckling behavior, P:synaptic growth at neuromuscular junction, P:visual learning, C:integral component of membrane, C:cytoplasmic vesicle, C:plasma membrane, F:peptidase activity, P:negative regulation of endopeptidase activity, P:proteolysis, C:integral to plasma membrane, P:G2 phase of mitotic cell cycle, P:induction of apoptosis, C:integral to membrane
UniProt3D-structure, Alternative splicing, Alzheimer disease, Amyloid, Amyloidosis, Apoptosis, Cell adhesion, Coated pit, Complete proteome, Copper, Direct protein sequencing, Disease mutation, Disulfide bond, Endocytosis, Glycoprotein, Heparin-binding, Iron, Membrane, Metal-binding, Neurodegeneration, Notch signaling pathway, Phosphoprotein, Polymorphism, Protease inhibitor, Proteoglycan, Reference proteome, Serine protease inhibitor, Signal, Transmembrane, Transmembrane helix, Zinc, Hydrolase, Protease
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseP-valueDetectionPubMed/DOI
Exp17106732Homo sapiens12heartendocardiumDCMi (Inflammatory dilated cardiomyopathy (DCMi))4.72E-04Gene-array17106732

Compile date 02-09-2018© C/VD project