cvd-logocvd - Molecule ID A105F

geneAPEX2, APE2, APEXL2
nameDNA-(apurinic or apyrimidinic site) lyase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APEX2_HUMANQ9UBZ4ENSG0000016918827301Hs.659558300773

Functions and classifications

GOC:chylomicron, C:early endosome, C:intermediate-density lipoprotein particle, C:low-density lipoprotein particle, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:lipase inhibitor activity, F:lipid binding, F:lipoprotein lipase activator activity, F:phospholipase activator activity, F:protein homodimerization activity, P:cholesterol efflux, P:cholesterol homeostasis, P:chylomicron remnant clearance, P:chylomicron remodeling, P:high-density lipoprotein particle clearance, P:lipid catabolic process, P:lipoprotein metabolic process, P:lipoprotein transport, P:negative regulation of cholesterol transport, P:negative regulation of lipid metabolic process, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of very-low-density lipoprotein particle clearance, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of fatty acid biosynthetic process, P:positive regulation of lipoprotein lipase activity, P:positive regulation of phospholipase activity, P:positive regulation of phospholipid catabolic process, P:positive regulation of triglyceride catabolic process, P:positive regulation of very-low-density lipoprotein particle remodeling, P:response to drug, P:retinoid metabolic process, P:reverse cholesterol transport, P:small molecule metabolic process, P:triglyceride homeostasis, P:very-low-density lipoprotein particle remodeling, F:enzyme activator activity, P:lipid metabolic process, P:lipid transport, P:positive regulation of catalytic activity
UniProtCell cycle, Complete proteome, Cytoplasm, DNA damage, DNA recombination, DNA repair, DNA-binding, Endonuclease, Exonuclease, Hydrolase, Lyase, Magnesium, Metal-binding, Mitochondrion, Nuclease, Nucleus, Polymorphism, Reference proteome
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.456<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.916<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)1.140<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))1.140<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.310<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.339<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))1.827<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.414<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project