cvd-logocvd - Molecule ID A1050

geneHIPK2, PRO0593
nameHomeodomain-interacting protein kinase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
HIPK2_HUMANQ9H2X6ENSG0000006439328996Hs.731417606868

Functions and classifications

GOC:centrosome, C:cytoplasm, C:nuclear body, C:nuclear membrane, C:PML body, F:ATP binding, F:protein serine/threonine kinase activity, F:RNA polymerase II activating transcription factor binding, F:RNA polymerase II transcription coactivator activity, F:transcription corepressor activity, F:virion binding, P:adult walking behavior, P:anterior/posterior pattern specification, P:cellular response to hypoxia, P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, P:embryonic camera-type eye morphogenesis, P:embryonic retina morphogenesis in camera-type eye, P:erythrocyte differentiation, P:eye development, P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, P:iris morphogenesis, P:lens induction in camera-type eye, P:modulation by virus of host morphology or physiology, P:negative regulation of BMP signaling pathway, P:negative regulation of neuron apoptotic process, P:negative regulation of transcription from RNA polymerase II promoter, P:neuron differentiation, P:peptidyl-serine phosphorylation, P:peptidyl-threonine phosphorylation, P:PML body organization, P:positive regulation of angiogenesis, P:positive regulation of cell proliferation, P:positive regulation of DNA binding, P:positive regulation of JNK cascade, P:positive regulation of protein binding, P:positive regulation of sequence-specific DNA binding transcription factor activity, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of transforming growth factor beta receptor signaling pathway, P:regulation of cell cycle, P:retina layer formation, P:SMAD protein signal transduction, P:smoothened signaling pathway, P:transcription from RNA polymerase II promoter, P:transforming growth factor beta receptor signaling pathway, P:voluntary musculoskeletal movement, F:DNA binding, F:protein kinase activity, P:virus-host interaction, C:centrosome, C:cytoplasm, C:nuclear body, C:nuclear membrane, C:PML body, F:ATP binding, F:protein serine/threonine kinase activity, F:RNA polymerase II activating transcription factor binding, F:RNA polymerase II transcription coactivator activity, F:transcription corepressor activity, F:virion binding, P:adult walking behavior, P:anterior/posterior pattern specification, P:cellular response to hypoxia, P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, P:embryonic camera-type eye morphogenesis, P:embryonic retina morphogenesis in camera-type eye, P:erythrocyte differentiation, P:eye development, P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, P:iris morphogenesis, P:lens induction in camera-type eye, P:modulation by virus of host morphology or physiology, P:negative regulation of BMP signaling pathway, P:negative regulation of neuron apoptotic process, P:negative regulation of transcription from RNA polymerase II promoter, P:neuron differentiation, P:peptidyl-serine phosphorylation, P:peptidyl-threonine phosphorylation, P:PML body organization, P:positive regulation of angiogenesis, P:positive regulation of cell proliferation, P:positive regulation of DNA binding, P:positive regulation of JNK cascade, P:positive regulation of protein binding, P:positive regulation of sequence-specific DNA binding transcription factor activity, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of transforming growth factor beta receptor signaling pathway, P:regulation of cell cycle, P:retina layer formation, P:SMAD protein signal transduction, P:smoothened signaling pathway, P:transcription from RNA polymerase II promoter, P:transforming growth factor beta receptor signaling pathway, P:voluntary musculoskeletal movement, F:DNA binding, F:protein kinase activity, P:virus-host interaction
UniProtAlternative splicing, Apoptosis, ATP-binding, Complete proteome, Cytoplasm, DNA damage, Isopeptide bond, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Serine/threonine-protein kinase, Transcription, Transcription regulation, Transferase, Ubl conjugation, DNA-binding, Homeobox
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17106732Homo sapiens12heartendocardiumDCMi (Inflammatory dilated cardiomyopathy (DCMi)) 5.15E-05Gene-array17106732
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)0.824<0.05Gene-array19059264
Exp21173733Homo sapiens10bloodwholeAtherosclerosis (Atherosclerosis familial hypercholesterolemia) 0.0110181Gene-array21173733
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.916<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)0.799<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))0.799<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.217<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.366<0.05Gene-array24530965
Exp24801707Homo sapiens52blood AMI (Myocardial infarction) 0.03863Whole-genome gene expression24801707
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))1.433<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.535<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project