cvd-logocvd - Molecule ID A0922

geneNCOR2, CTG26
nameNuclear receptor co-repressor 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
NCOR2_HUMANQ9Y618ENSG000001964989612Hs.137510600848

Functions and classifications

GOC:nuclear body, C:nuclear matrix, C:nucleus, C:transcriptional repressor complex, F:chromatin binding, F:DNA binding, F:transcription corepressor activity, P:cellular lipid metabolic process, P:negative regulation of transcription from RNA polymerase II promoter, P:Notch signaling pathway, P:regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter, P:small molecule metabolic process, P:transcription initiation from RNA polymerase II promoter, P:transforming growth factor beta receptor signaling pathway, C:chromatin, C:histone deacetylase complex, F:RNA polymerase II regulatory region DNA binding, F:sequence-specific DNA binding, P:cell proliferation in forebrain, P:estrous cycle phase, P:glucose homeostasis, P:heart morphogenesis, P:in utero embryonic development, P:lactation, P:negative regulation of fat cell differentiation, P:response to estradiol, P:response to organonitrogen compound, P:telencephalon development, P:Type I pneumocyte differentiation, P:white fat cell differentiation, C:nuclear body, C:nuclear matrix, C:nucleus, C:transcriptional repressor complex, F:chromatin binding, F:DNA binding, F:transcription corepressor activity, P:cellular lipid metabolic process, P:negative regulation of transcription from RNA polymerase II promoter, P:Notch signaling pathway, P:regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter, P:small molecule metabolic process, P:transcription initiation from RNA polymerase II promoter, P:transforming growth factor beta receptor signaling pathway, C:chromatin, C:histone deacetylase complex, F:RNA polymerase II regulatory region DNA binding, F:sequence-specific DNA binding, P:cell proliferation in forebrain, P:estrous cycle phase, P:glucose homeostasis, P:heart morphogenesis, P:in utero embryonic development, P:lactation, P:negative regulation of fat cell differentiation, P:response to estradiol, P:response to organonitrogen compound, P:telencephalon development, P:Type I pneumocyte differentiation, P:white fat cell differentiation
UniProt3D-structure, Acetylation, Alternative splicing, Coiled coil, Complete proteome, DNA-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Repressor, Transcription, Transcription regulation
PADBTF: transcription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15769906aHomo sapiens19heartmyocardiumNICM (Pre-LVAD, nonischemic cardiomyopathy) 4.77E-07Gene-array15769906
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)0.713<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))1.086<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)1.323<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))1.323<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.590<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))1.417<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))1.361<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))4.309<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project