cvd-logocvd - Molecule ID A0875

geneIL1R1, IL1R, IL1RA
nameInterleukin-1 receptor, type I precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
IL1R1_HUMANP14778ENSG000001155943554Hs.701982147810

Functions and classifications

GOC:cell surface, C:extracellular region, C:integral component of plasma membrane, F:interleukin-1, Type I, activating receptor activity, P:immune response, P:regulation of inflammatory response, P:interleukin-1-mediated signaling pathway, F:interleukin-1, Type I, activating receptor activity, P:interleukin-1-mediated signaling pathway, F:interleukin-1 receptor activity, P:cytokine-mediated signaling pathway, C:integral to plasma membrane, C:intracellular, P:innate immune response, P:ovulation, P:response to nitric oxide, C:intracellular, C:intrinsic to membrane, C:integral to membrane, C:integral to membrane
UniProt3D-structure, Cell membrane, Complete proteome, Disulfide bond, Glycoprotein, Immunoglobulin domain, Membrane, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Repeat, Secreted, Signal, Transmembrane, Transmembrane helix
PADBTM: transmembrane

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.103<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.936<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)0.734<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))0.734<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.466<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.277<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))1.762<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.182<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project