cvd-logocvd - Molecule ID A0686

geneAP1B1, ADTB1, BAM22
nameAP-1 complex subunit beta-1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AP1B1_HUMANQ10567ENSG00000100280162Hs.368794600157

Functions and classifications

GOC:extracellular space, C:extracellular vesicular exosome, C:plasma membrane, F:C5L2 anaphylatoxin chemotactic receptor binding, F:endopeptidase inhibitor activity, P:complement activation, alternative pathway, P:complement activation, classical pathway, P:fatty acid metabolic process, P:G-protein coupled receptor signaling pathway, P:inflammatory response, P:negative regulation of endopeptidase activity, P:positive regulation of activation of membrane attack complex, P:positive regulation of angiogenesis, P:positive regulation of G-protein coupled receptor protein signaling pathway, P:positive regulation of glucose transport, P:positive regulation of lipid storage, P:positive regulation of phagocytosis, P:positive regulation of protein phosphorylation, P:positive regulation of type IIa hypersensitivity, P:positive regulation vascular endothelial growth factor production, P:regulation of complement activation, P:regulation of triglyceride biosynthetic process, P:complement activation, C:extracellular region
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Cytoplasmic vesicle, Golgi apparatus, Membrane, Nitration, Polymorphism, Protein transport, Reference proteome, Transport, Endocytosis
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.137<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))0.841<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)0.691<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))0.691<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.599<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.608<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))0.724<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.207<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project