cvd-logocvd - Molecule ID A0579

geneDCC, IGDCC1
nameNetrin receptor DCC
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
DCC_HUMANP43146ENSG000001873231630Hs.162025120470, 157600

Functions and classifications

GOC:axon, C:cytosol, C:growth cone membrane, C:integral component of membrane, C:membrane raft, C:plasma membrane, F:netrin receptor activity, F:transcription coactivator activity, F:transmembrane signaling receptor activity, P:anterior/posterior axon guidance, P:apoptotic process, P:axon guidance, P:dorsal/ventral axon guidance, P:negative regulation of collateral sprouting, P:negative regulation of dendrite development, P:neuron migration, P:positive regulation of apoptotic process, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of neuron projection development, P:regulation of RNA biosynthetic process, P:response to amphetamine, P:spinal cord ventral commissure morphogenesis, C:integral to membrane, P:induction of apoptosis, P:netrin-activated signaling pathway
UniProt3D-structure, Apoptosis, Complete proteome, Developmental protein, Disulfide bond, Glycoprotein, Immunoglobulin domain, Membrane, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Repeat, Signal, Transmembrane, Transmembrane helix, Tumor suppressor, Ubl conjugation
PADBRCP: receptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)1.114<0.05Gene-array19059264
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))1.046<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)2.770<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))2.770<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.370<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))1.300<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))2.334<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))0.472<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project