cvd-logocvd - Molecule ID A0480

geneBCL2A1, BCL2L5, BFL1
nameBcl-2-related protein A1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
B2LA1_HUMANQ16548ENSG00000140379597Hs.227817601056

Functions and classifications

GOC:mitochondrial outer membrane, F:protein heterodimerization activity, F:protein homodimerization activity, P:extrinsic apoptotic signaling pathway in absence of ligand, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:negative regulation of apoptotic process, P:negative regulation of intrinsic apoptotic signaling pathway, C:cytoplasm, P:apoptotic process, C:mitochondrial outer membrane, F:protein heterodimerization activity, F:protein homodimerization activity, P:extrinsic apoptotic signaling pathway in absence of ligand, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:negative regulation of apoptotic process, P:negative regulation of intrinsic apoptotic signaling pathway, C:cytoplasm, P:apoptotic process
UniProt3D-structure, Alternative splicing, Apoptosis, Complete proteome, Cytoplasm, Polymorphism, Reference proteome
PADBSIG: signalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19059264Homo sapiens31bloodmonocytes and T-helper cellsAtherosclerosis (Coronary Atherosclerosis)0.715<0.05Gene-array19059264
Exp19336532bHomo sapiens24bloodmononuclear cellsNICM (Non-ischemic dilated cardiomyopathy (NIDCM) ) 0.0052309Gene-array19336532
Exp21804111Mus musculus9aorta CAD (Coronary artery disease (CAD))1.099<0.05Gene-array21804111
Exp21868699aMus musculus20macrophages Atherosclerosis (Atherosclerosis)0.669<0.05Gene-array21868699
Exp21868699bMus musculus40aorta and macrophages CAD (Coronary artery disease (CAD))0.669<0.05Gene-array21868699
Exp24082102Mus musculus88heartwholeCAD (Coronary artery disease (CAD))1.556<0.05Gene-array24082102
Exp24530965Homo sapiens23bloodmononuclear cells (PBMCs)CAD (Familial Hypercholesterolemia and Coronary artery disease (CAD))0.406<0.05Gene-array24530965
Exp25835000Homo sapiens31macrophages CAD (Coronary artery disease (CAD))0.656<0.05Gene-array25835000
Exp27142736Mus musculus12liver CAD (Coronary artery disease (CAD))1.982<0.05Gene-array27142736

Compile date 02-09-2018© C/VD project