CKDdb-logoCKDdb - Study ID Exp23291264b

PubMed ID23291264
AuthorsNishihara K, Masuda S, Shinke H, Ozawa A, Ichimura T, Yonezawa A, Nakagawa S, Inui K, Bonventre JV, Matsubara K.
TitleUrinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity.
JournalBiochem Pharmacol. 2013 Feb 15;85(4):570-82.
AbstractBecause of the difficulty in detecting segment-specific response in the kidney, we investigated the molecular events underlying acute kidney injury in the proximal tubules of rats with cisplatin (cis-diamminedichloroplatinum II)-induced nephrotoxicity. Microarray analysis revealed that mRNA levels of several cytokines and chemokines, such as interleukin-1beta, chemokine (C-C motif) ligand (CCL) 2, CCL20, chemokine (C-X-C motif) ligand (CXCL) 1, and CXCL10 were significantly increased after cisplatin treatment in both isolated proximal tubules and whole kidney. Interestingly, tubular CCL2 mRNA levels increased soon after cisplatin administration, whereas CCL2 mRNA levels in whole kidney first decreased and then increased. Levels of both CCL2 and kidney injury molecule-1 (KIM-1) in the whole kidney increased after cisplatin administration. Immunofluorescence analysis revealed CCL2 changes in the proximal tubular cells initially and then in the medullary interstitium. Urinary CCL2 excretion significantly increased approximately 3-fold compared with controls the day after cisplatin administration (5mg/kg), when no changes were observed plasma creatinine and blood urea nitrogen levels. Urinary levels of KIM-1 also increased 3-fold after cisplatin administration. In addition, urinary CCL2 rather than KIM-1 increased in chronic renal failure rats after administration of low-dose cisplatin (2mg/kg), suggesting that urinary CCL2 was selective for cisplatin-induced nephrotoxicity in renal impairment. These results indicated that the increase in cytokine and chemokine expression in renal epithelial cells might be responsible for kidney deterioration in cisplatin-induced nephrotoxicity, and that urinary CCL2 is associated with tubular injury and serves as a sensitive and noninvasive marker for the early detection of cisplatin-induced tubular injury.

Sample characteristics

SpeciesTissue / SourceCompartmentDiseaseDetection methodSample
Rattus norvegicuskidneyproximal tubulecisplatin_inducedRNA microarrayDem23291264

Sample description and preparation

Disease (case)cisplatin-induced nephrotoxicity
Disease (control)healthy, sham-control
Disease inductioncisplatin (10 mg/kg), 2 days
Preparation specific methodRNeasy Mini Kit

Sample detection

Array versionABI Rat Genome Survey

Molecule list

Molecule IDextExternal IDGeneNameSource accRegulation (case/control)Scores
A0016 DLG3_RATDlgh3, Dlg3Disks large homolog 321151763p-value: 0.00306
A0054 GNAI1_RATGnai-1, Gnai1Guanine nucleotide-binding protein G(i) subunit alpha-121408905p-value: 0.0101
A0054 GNAI1_RATGnai-1, Gnai1Guanine nucleotide-binding protein G(i) subunit alpha-121408905p-value: 0.0123
A0077 NRG1_RATNdf, Nrg1Pro-neuregulin-121951725p-value: 0.0437
A0077 NRG1_RATNdf, Nrg1Pro-neuregulin-121951725p-value: 0.0000039
A009C GOSR2_RATGs27, Gosr2Golgi SNAP receptor complex member 221688519p-value: 0.00303
A0107 DLGP1_RATGkap, Dlgap1Disks large-associated protein 121570255p-value: 0.00442
A0117 NSF_RATErg1Vesicle-fusing ATPase21223880p-value: 0.000722
A0117 NSF_RATErg1Vesicle-fusing ATPase21223880p-value: 0.0112
A0135 TAU_RATMtapt, TauMicrotubule-associated protein tau21967602p-value: 0.0000695
A013C GTR5_RATGlut5, Slc2a5Solute carrier family 220882596p-value: 0.00212
A013C GTR5_RATGlut5, Slc2a5Solute carrier family 220882596p-value: 0.000000031
A0147XPP1A_RATPpp1a, Ppp1caSerine/threonine-protein phosphatase PP1-alpha catalytic subunit21594861p-value: 0.00207
A0154 ITPR1_RATInsp3r, Itpr1Inositol 121488499p-value: 0.0000745
A0154 ITPR1_RATInsp3r, Itpr1Inositol 121488499p-value: 0.0156
A0179 WIPF1_RATWaspip, WipWAS/WASL-interacting protein family member 122378251p-value: 0.00306
A0181 MK01_RATErk2, MapkMitogen-activated protein kinase 121502436p-value: 0.00105
A0201XRASK_RATKras2, KrasGTPase KRas20836109p-value: 0.000419
A0201XRASK_RATKras2, KrasGTPase KRas20836109p-value: 0.00000176
A0205 PLD1_RATPld1Phospholipase D122285714p-value: 0.0000649
A0219 CADH2_RATCdh2Cadherin-221081897p-value: 0.000285
A0219 CADH2_RATCdh2Cadherin-221081897p-value: 0.00000139
A023F ASNS_RATAsnsAsparagine synthetase [glutamine-hydrolyzing]22408327p-value: 0.00000117
A0301 GRIP1_RATGrip1Glutamate receptor-interacting protein 122276618p-value: 0.0000519
A0313 FAK1_RATFak, Fak1Focal adhesion kinase 121475654p-value: 0.00503
A0342 AT1A3_RATAtp1a3Sodium/potassium-transporting ATPase subunit alpha-321945469p-value: 0.0052
A036A PDGFC_RATScdgfPlatelet-derived growth factor C20800589p-value: 0.00113
A036H E9PTK6Kifc2Protein Kifc221478588p-value: 0.00115
A036H E9PTK6Kifc2Protein Kifc221478588p-value: 0.0217
A0426XVDAC2_RATVdac2Voltage-dependent anion-selective channel protein 222077396p-value: 0.00956
A0429XACON_RATAco2Aconitate hydratase21496728p-value: 0.00568
A0433 TPIS_RATTpi1Triosephosphate isomerase21623507p-value: 0.00484
A045G CXB5_RATCxn-31.1Gap junction beta-5 protein21623671p-value: 0.036
A045G CXB5_RATCxn-31.1Gap junction beta-5 protein21623671p-value: 0.00000774
A0461 DDAH1_RATDdah, Ddah1N(G),N(G)-dimethylarginine dimethylaminohydrolase 122365019p-value: 0.000471
A0461 DDAH1_RATDdah, Ddah1N(G),N(G)-dimethylarginine dimethylaminohydrolase 122365019p-value: 0.0349
A0475XMK13_RATMapk13Mitogen-activated protein kinase 1321981980p-value: 0.000549
A0476 BAD_RATBadBcl2-associated agonist of cell death22308589p-value: 0.000865
A0487 HMOX2_RATHmox2Heme oxygenase 221851284p-value: 0.000801
A0487 HMOX2_RATHmox2Heme oxygenase 221851284p-value: 0.00687
A0494XYBOX3_RATCsda, DbpaY-box-binding protein 321272167p-value: 0.00162
A0494XYBOX3_RATCsda, DbpaY-box-binding protein 321272167p-value: 0.00374
A0512XMPDZ_RATMupp1, MpdzMultiple PDZ domain protein21383254p-value: 0.0000214
A0518 GHR_RATGhr, GHR/BPGrowth hormone receptor21960505p-value: 0.000597
A0518 GHR_RATGhr, GHR/BPGrowth hormone receptor21960505p-value: 0.000286
A0536 S10A6_RATCacy, S100a6Protein S100-A621480545p-value: 0.0000316
A0536 S10A6_RATCacy, S100a6Protein S100-A621480545p-value: 0.000000393
A0537XANXA2_RATAnx2Annexin A222147762p-value: 0.000351
A0537XANXA2_RATAnx2Annexin A222147762p-value: 0.000151
A0549 Q9ET45Bnip3BCL2/adenovirus E1B 19 kDa-interacting protein 320721889p-value: 0.000851
A054G CXXC5_RATCxxc5CXXC-type zinc finger protein 521306433p-value: 0.000437
A0562 STXB5_RATLlgl3, Stxbp5Syntaxin-binding protein 520929555p-value: 0.000346
A0562 STXB5_RATLlgl3, Stxbp5Syntaxin-binding protein 520929555p-value: 0.00407
A0567 GDIA_RATRabgdia, Gdi1Rab GDP dissociation inhibitor alpha21260406p-value: 0.000547
A0611 5HT2C_RAT5ht1c, Htr1c5-hydroxytryptamine receptor 2C21905876p-value: 0.00548
A0636XDNJC5_RATCspDnaJ homolog subfamily C member 520857438p-value: 0.00065
A0636XDNJC5_RATCspDnaJ homolog subfamily C member 520857438p-value: 0.00134
A0637XGEPH_RATGph, GphnGephyrin21396855p-value: 0.000694
A0637XGEPH_RATGph, GphnGephyrin21396855p-value: 0.00248
A0647XANXA1_RATAnx1, Anxa1Annexin A120845281p-value: 0.000142
A0648 S10AA_RATS100a10, p11Protein S100-A1020938158p-value: 0.0000439
A0648 S10AA_RATS100a10, p11Protein S100-A1020938158p-value: 0.000283
A0740XANDR_RATNr3c4Androgen receptor21272180p-value: 0.0000664
A0740XANDR_RATNr3c4Androgen receptor21272180p-value: 0.018
A074CXKIFC1_RATKrp1, Kifc1Kinesin-like protein KIFC121873387p-value: 0.00384
A074CXKIFC1_RATKrp1, Kifc1Kinesin-like protein KIFC121873387p-value: 0.00284
A0761 KCJ16_RATKcnj16Inward rectifier potassium channel 1621749912p-value: 0.00407
A0761 KCJ16_RATKcnj16Inward rectifier potassium channel 1621749912p-value: 0.000573
A0779XAN32A_RATLanp, Anp32aAcidic leucine-rich nuclear phosphoprotein 32 family member A22324938p-value: 0.0143
A0779XAN32A_RATLanp, Anp32aAcidic leucine-rich nuclear phosphoprotein 32 family member A22324938p-value: 0.00108
A0826 SL9A3_RATNhe3, Slc9a3Sodium/hydrogen exchanger 321041351p-value: 0.00000266
A0826 SL9A3_RATNhe3, Slc9a3Sodium/hydrogen exchanger 321041351p-value: 0.0145
A082FXTHB_RATErba2, Nr1a2Thyroid hormone receptor beta21570656p-value: 0.00000627
A082FXTHB_RATErba2, Nr1a2Thyroid hormone receptor beta21570656p-value: 0.0275
A0848 FHIT_RATFhitBis(5'-adenosyl)-triphosphatase21765463p-value: 0.000454
A0848 FHIT_RATFhitBis(5'-adenosyl)-triphosphatase21765463p-value: 0.00000199
A0851 ROS1_RATRos1Proto-oncogene tyrosine-protein kinase ROS20757739p-value: 0.00147
A0877XTNR1A_RATTnfr-1, Tnfr1Tumor necrosis factor receptor superfamily member 1A22119667p-value: 0.00106
A0877XTNR1A_RATTnfr-1, Tnfr1Tumor necrosis factor receptor superfamily member 1A22119667p-value: 0.0215
A088I RES18_RATResp18Regulated endocrine-specific protein 1822021603p-value: 0.00575
A088I RES18_RATResp18Regulated endocrine-specific protein 1822021603p-value: 0.00267
A0911 MTOR_RATFrap1, Raft1Serine/threonine-protein kinase mTOR20811570p-value: 0.00109
A0911 MTOR_RATFrap1, Raft1Serine/threonine-protein kinase mTOR20811570p-value: 0.0199
A0933XGCR_RATGrl, Nr3c1Glucocorticoid receptor21842921p-value: 0.00173
A0933XGCR_RATGrl, Nr3c1Glucocorticoid receptor21842921p-value: 0.00829
A096K Q8R430Okl38OKL38-2.321310129p-value: 0.00000169
A0978XPYGL_RATLgpGlycogen phosphorylase21268282p-value: 0.0012
A0978XPYGL_RATLgpGlycogen phosphorylase21268282p-value: 0.00178
A1004XMYPT1_RATMbs, Mypt1Protein phosphatase 1 regulatory subunit 12A22140289p-value: 0.000269
A1015 BAIP2_RATBaiap2Brain-specific angiogenesis inhibitor 1-associated protein 220956062p-value: 0.000349
A1054 MXI1_RATMxi1, LOC100360467Max-interacting protein 120950254p-value: 0.00152
A1054 MXI1_RATMxi1, LOC100360467Max-interacting protein 120950254p-value: 0.00000261
A1064 RHG17_RATArhgap17Rho GTPase-activating protein 1721026349p-value: 0.000179
A1121 Q5U2Y4Nedd9Neural cell expressed21306865p-value: 0.00451
A1140 FZD1_RATFzd1Frizzled-122120236p-value: 0.00024
A1163 NCDN_RATNcdnNeurochondrin21032699p-value: 0.00194
A1163 NCDN_RATNcdnNeurochondrin21032699p-value: 0.000962
A1168XSI1L1_RATSpa1, Sipa1l1Signal-induced proliferation-associated 1-like protein 122159927p-value: 0.00208
A1168XSI1L1_RATSpa1, Sipa1l1Signal-induced proliferation-associated 1-like protein 122159927p-value: 0.0269
A116A SE1L1_RATSel1h, Sel1lProtein sel-1 homolog 120721657p-value: 0.0028
A1217XLEG1_RATLgals1Galectin-121243387p-value: 0.00765
A1229XQ5U2T9Fkbp5FK506 binding protein 521290384p-value: 0.0033
A123C MOT10_RATMct10, Tat1Monocarboxylate transporter 1021949794p-value: 0.000963
A1250 UB2V2_RATMms2, Uev2Ubiquitin-conjugating enzyme E2 variant 220885708p-value: 0.00168
A1283 PLK2_RATSnkSerine/threonine-protein kinase PLK221712966p-value: 0.000000192
A1283 PLK2_RATSnkSerine/threonine-protein kinase PLK221712966p-value: 0.000000446
A1345XQ5U2Z4Nfkb2Nuclear factor of kappa light polypeptide gene enhancer in B-cells 222099021p-value: 0.00119
A1345XQ5U2Z4Nfkb2Nuclear factor of kappa light polypeptide gene enhancer in B-cells 222099021p-value: 0.0161
A1376 Q64315cip1, WAF1Cyclin-dependent kinase inhibitor 1A21665931p-value: 0.0000634
A1376 Q64315cip1, WAF1Cyclin-dependent kinase inhibitor 1A21665931p-value: 0.0000434
A1408 RBL2_RATRbl2Retinoblastoma-like protein 220712530p-value: 0.000109
A1495 PAI1_RATPai1, Planh1Plasminogen activator inhibitor 121669459p-value: 0.00502
A1496 TPA_RATPlatTissue-type plasminogen activator21634180p-value: 0.00513
A1496 TPA_RATPlatTissue-type plasminogen activator21634180p-value: 0.00867
A1497XUROK_RATPlauUrokinase-type plasminogen activator21568487p-value: 0.00175
A1497XUROK_RATPlauUrokinase-type plasminogen activator21568487p-value: 0.00569
A1503 PROC_RATProcVitamin K-dependent protein C21803961p-value: 0.0048
A1503 PROC_RATProcVitamin K-dependent protein C21803961p-value: 0.000656
A1526 OSTP_RAT2b7, Spp-1Osteopontin21078247p-value: 0.000885
A1526 OSTP_RAT2b7, Spp-1Osteopontin21078247p-value: 0.000023
A154H LMO3_RATLmo3, RGD1561357LIM domain only protein 322239669p-value: 0.0373
A154H LMO3_RATLmo3, RGD1561357LIM domain only protein 322239669p-value: 0.000203
A156G Q5U2V7DonsonDownstream neighbor of SON21080583p-value: 0.000191
A1582 PDGFA_RATRpa1, PdgfaPlatelet-derived growth factor subunit A20878482p-value: 0.00146
A1596 C1QA_RATC1qaComplement C1q subcomponent subunit A ( Precursor)21644783p-value: 0.0128
A162A Q5PQL1Tnfsf13Protein Tnfsf1320755599p-value: 0.0104
A162A Q5PQL1Tnfsf13Protein Tnfsf1320755599p-value: 0.000136
A1659 CCL2_RATJe, Mcp1C-C motif chemokine 220907835p-value: 0.000233
A1659 CCL2_RATJe, Mcp1C-C motif chemokine 220907835p-value: 0.0021
A1693XITA7_RATItga7Integrin alpha-721358302p-value: 0.00636
A1693XITA7_RATItga7Integrin alpha-721358302p-value: 0.000131
A1708 C1QC_RATC1qgComplement C1q subcomponent subunit C ( Precursor)22357996p-value: 0.00774
A1778 HBEGF_RATDtr, HegflProheparin-binding EGF-like growth factor20983420p-value: 0.00000276
A1778 HBEGF_RATDtr, HegflProheparin-binding EGF-like growth factor20983420p-value: 0.000000998
A1784 Q9ERE0Ccl17Thymus and activation-regulated chemokine22219977p-value: 0.00126
A1795 CXCL2_RATCinc3, Mip-2C-X-C motif chemokine 220807096p-value: 0.0019
A1795 CXCL2_RATCinc3, Mip-2C-X-C motif chemokine 220807096p-value: 0.000256
A347J AGTRA_RATAgtr1, Agtr1a, At1aType-1A angiotensin II receptor21329950p-value: 0.000602
A180E UBC_RATUbc, LOC100363345Polyubiquitin-C22415427p-value: 0.000387
A180J WRB_RATWrbTail-anchored protein insertion receptor WRB21794080p-value: 0.00963
A1818 TAP1_RATAbcb2, Mtp1Antigen peptide transporter 121235791p-value: 0.000572
A1840 ABCB9_RATAbcb9ATP-binding cassette sub-family B member 921845717p-value: 0.000689
A185C NAGT1_RATRGD1559971, RGD1561777Sodium-dependent glucose transporter 120979833p-value: 0.00303
A185C NAGT1_RATRGD1559971, RGD1561777Sodium-dependent glucose transporter 120979833p-value: 0.0000844
A1866 KCJ12_RATIrk2, Kcnj12ATP-sensitive inward rectifier potassium channel 1221686638p-value: 0.0000622
A1866 KCJ12_RATIrk2, Kcnj12ATP-sensitive inward rectifier potassium channel 1221686638p-value: 0.00029
A1924 ALDOB_RATAldobFructose-bisphosphate aldolase B21925486p-value: 0.0049
A1924 ALDOB_RATAldobFructose-bisphosphate aldolase B21925486p-value: 0.000564
A192C NDEL1_RATNude2, NudelNuclear distribution protein nudE-like 121661938p-value: 0.0197
A192C NDEL1_RATNude2, NudelNuclear distribution protein nudE-like 121661938p-value: 0.0000518
A1952 GSTK1_RATGstk1Glutathione S-transferase kappa 121331658p-value: 0.0104
A1952 GSTK1_RATGstk1Glutathione S-transferase kappa 121331658p-value: 0.0438
A6670XGSTT2_RATGstt2Glutathione S-transferase theta-221796127p-value: 0.000111
A197B Q672J3Zbtb1Protein Zbtb122395669p-value: 0.000583
A197B Q672J3Zbtb1Protein Zbtb122395669p-value: 0.00491
A2024XQ8CHN9Smcf1, smctf-1Transcription factor 121866956p-value: 0.000798
A203J Q5XI44Xrcc4Protein Xrcc421464712p-value: 0.00000246
A212F ABTB2_RATCca3, Abtb2Ankyrin repeat and BTB/POZ domain-containing protein 221531200p-value: 0.000893
A212F ABTB2_RATCca3, Abtb2Ankyrin repeat and BTB/POZ domain-containing protein 221531200p-value: 0.00397
A213I RSLBB_RATRasl11bRas-like protein family member 11B22110465p-value: 0.00191
A220CXNDUV3_RATNdufv3, Ndufv3lNADH dehydrogenase [ubiquinone] flavoprotein 322013882p-value: 0.00219
A222B ZFN2A_RATZfand2aAN1-type zinc finger protein 2A21349481p-value: 0.00000767
A222B ZFN2A_RATZfand2aAN1-type zinc finger protein 2A21349481p-value: 0.0000764
A224C NGAL_RATLcn2Neutrophil gelatinase-associated lipocalin21297561p-value: 0.000708
A224C NGAL_RATLcn2Neutrophil gelatinase-associated lipocalin21297561p-value: 0.000000105
A2275 Q7TQ24Kctd13PDIP122271164p-value: 0.0265
A2300 KCNB1_RATKcnb1Potassium voltage-gated channel subfamily B member 120889867p-value: 0.000306
A2300 KCNB1_RATKcnb1Potassium voltage-gated channel subfamily B member 120889867p-value: 0.0198
A2302 KCNS2_RATKcns2Potassium voltage-gated channel subfamily S member 220920738p-value: 0.00474
A2302 KCNS2_RATKcns2Potassium voltage-gated channel subfamily S member 220920738p-value: 0.000000316
A2344XACTN4_RATActn4Alpha-actinin-422066307p-value: 0.00372
A234CXNPT2A_RATSlc17a2, NaPi-2Sodium-dependent phosphate transport protein 2A22155570p-value: 0.000114
A2355 RHG24_RATArhgap24Rho GTPase-activating protein 2422281574p-value: 0.000146
A2355 RHG24_RATArhgap24Rho GTPase-activating protein 2422281574p-value: 0.0267
A235I S12A8_RATCcc9, Slc12a8Solute carrier family 12 member 820742389p-value: 0.000122
A235I S12A8_RATCcc9, Slc12a8Solute carrier family 12 member 820742389p-value: 0.00000215
A236C NPT2C_RATSlc34a3Sodium-dependent phosphate transport protein 2C21770029p-value: 0.000108
A236I S13A1_RATNas1, Nasi1Solute carrier family 13 member 121280496p-value: 0.000521
A236I S13A1_RATNas1, Nasi1Solute carrier family 13 member 121280496p-value: 0.0038
A2451 DCA11_RATWdr23DDB1- and CUL4-associated factor 1121490169p-value: 0.0028
A2467 ENPP1_RATNpps, Pc1Ectonucleotide pyrophosphatase/phosphodiesterase family member 122030410p-value: 0.00381
A2468 ENPP3_RATPdnp3, Enpp3Ectonucleotide pyrophosphatase/phosphodiesterase family member 321938067p-value: 0.0000466
A2469 ENPP2_RATAtx, Npps2Ectonucleotide pyrophosphatase/phosphodiesterase family member 221378132p-value: 0.000047
A2476 STS_RATStsSteryl-sulfatase21376029p-value: 0.00025
A2476 STS_RATStsSteryl-sulfatase21376029p-value: 0.00616
A249F ADM2_RATAm2, Adm2ADM221456191p-value: 0.00207
A249F ADM2_RATAm2, Adm2ADM221456191p-value: 0.00758
A249H MAF_RATMaf2, MafTranscription factor Maf21784641p-value: 0.0000145
A2589 Q5PQR0RalyRCG3735320722041p-value: 0.00119
A266C OSBL1_RATOrp1, Osbpl1aOxysterol-binding protein-related protein 121264503p-value: 0.000104
A266C OSBL1_RATOrp1, Osbpl1aOxysterol-binding protein-related protein 121264503p-value: 0.0000768
A271F AJUBA_RATJubLIM domain-containing protein ajuba22226761p-value: 0.000342
A275I S35E4_RATSlc35e4, LOC266687Solute carrier family 35 member E421377214p-value: 0.000815
A275I S35E4_RATSlc35e4, LOC266687Solute carrier family 35 member E421377214p-value: 0.000257
A276E S10A4_RATS100a4Protein S100-A421475949p-value: 0.00227
A292CXPO210_RATGp210, Pom210Nuclear pore membrane glycoprotein 21021372975p-value: 0.00645
A294J S6A20_RATSit1, Xtrp3Sodium- and chloride-dependent transporter XTRP320777407p-value: 0.0068
A294J S6A20_RATSit1, Xtrp3Sodium- and chloride-dependent transporter XTRP320777407p-value: 0.00121
A297AXCNBP_RATZnf9, CnbpCellular nucleic acid-binding protein21342216p-value: 0.00219
A304IXS6A18_RATXtrp2, Slc6a18Sodium-dependent neutral amino acid transporter B(0)AT322152223p-value: 0.000223
A304IXS6A18_RATXtrp2, Slc6a18Sodium-dependent neutral amino acid transporter B(0)AT322152223p-value: 0.000689
A3110 Q9ESF3Bteb2Basic trancription element binding protein 220770519p-value: 0.00243
A3110 Q9ESF3Bteb2Basic trancription element binding protein 220770519p-value: 0.000322
A3113 KLF6_RATCopeb, Klf6Krueppel-like factor 621391739p-value: 0.000989
A3113 KLF6_RATCopeb, Klf6Krueppel-like factor 621391739p-value: 0.000383
A3114 Q5FVT6Klf15Klf15 protein20848336p-value: 0.0000756
A3114 Q5FVT6Klf15Klf15 protein20848336p-value: 0.0000114
A311J ZFAN3_RATTex27, Zfand3AN1-type zinc finger protein 322164821p-value: 0.00187
A3126 EGR2_RATEgr-2, Krox-20E3 SUMO-protein ligase EGR222295311p-value: 0.00224
A3126 EGR2_RATEgr-2, Krox-20E3 SUMO-protein ligase EGR222295311p-value: 0.00000134
A343E SPP24_RATSpp24Secreted phosphoprotein 2422297483p-value: 0.0000411
A343E SPP24_RATSpp24Secreted phosphoprotein 2422297483p-value: 0.00355
A343I SC6A6_RATSlc6a6Sodium- and chloride-dependent taurine transporter21400849p-value: 0.00344
A343I SC6A6_RATSlc6a6Sodium- and chloride-dependent taurine transporter21400849p-value: 0.0000115
A3485 S4A4_RATNbc, Nbc1Electrogenic sodium bicarbonate cotransporter 121943154p-value: 0.000731
A3521 SEPT9_RAT40057Septin-922352725p-value: 0.000369
A3533XHS105_RATHsp105, Hsp110Heat shock protein 105 kDa21832208p-value: 0.0127
A3561XNDUS1_RATNdufs1NADH-ubiquinone oxidoreductase 75 kDa subunit21409153p-value: 0.000717
A3561XNDUS1_RATNdufs1NADH-ubiquinone oxidoreductase 75 kDa subunit21409153p-value: 0.0242
A3585 AL1A1_RATAldhRetinal dehydrogenase 120872072p-value: 0.00487
A3602XPCCB_RATPccbPropionyl-CoA carboxylase beta chain20781569p-value: 0.00205
A3604 MCCA_RATMcca, Mccc1Methylcrotonoyl-CoA carboxylase subunit alpha21254188p-value: 0.0000696
A3604 MCCA_RATMcca, Mccc1Methylcrotonoyl-CoA carboxylase subunit alpha21254188p-value: 0.000468
A3609XDPYS_RATDpysDihydropyrimidinase20825630p-value: 0.0000465
A3609XDPYS_RATDpysDihydropyrimidinase20825630p-value: 0.0105
A3635 DHRS4_RATDhrs4Dehydrogenase/reductase SDR family member 422257078p-value: 0.000188
A3662XPYC_RATPcPyruvate carboxylase21567976p-value: 0.00000567
A3662XPYC_RATPcPyruvate carboxylase21567976p-value: 0.00326
A3680XDHE3_RATGlud, Glud1Glutamate dehydrogenase 121586769p-value: 0.000162
A3699 DECR_RATDecr, Decr12,4-dienoyl-CoA reductase, mitochondrial22130436p-value: 0.00167
A3701 DECR2_RATDecr2Peroxisomal 221480204p-value: 0.00363
A3701 DECR2_RATDecr2Peroxisomal 221480204p-value: 0.000018
A3707XDHB11_RATDhrs8Estradiol 17-beta-dehydrogenase 1121435497p-value: 0.000121
A3714 DHI1_RATHsd11, Hsd11b1Corticosteroid 11-beta-dehydrogenase isozyme 121812929p-value: 0.000466
A3714 DHI1_RATHsd11, Hsd11b1Corticosteroid 11-beta-dehydrogenase isozyme 121812929p-value: 0.0042
A3731 M2OM_RATSlc20a4, Slc25a11Mitochondrial 2-oxoglutarate/malate carrier protein20897236p-value: 0.00345
A3731 M2OM_RATSlc20a4, Slc25a11Mitochondrial 2-oxoglutarate/malate carrier protein20897236p-value: 0.000953
A3732 O89035Slc25a10Mitochondrial dicarboxylate carrier20869466p-value: 0.000022
A3745 MCAT_RATCact, Slc25a20Mitochondrial carnitine/acylcarnitine carrier protein22329795p-value: 0.00137
A3781XAIFM1_RATAif, Pdcd8Apoptosis-inducing factor 122393003p-value: 0.000629
A382C S13A3_RATNadc3, Sdct2Solute carrier family 13 member 321794702p-value: 0.000465
A3865 A3E0T0Epb4.1l3, Epb41l3Erythrocyte protein band 4.1-like 322216495p-value: 0.000514
A3877 ADDG_RATAdd3Gamma-adducin22300760p-value: 0.000168
A3883 PALM_RATPalmParalemmin-121196188p-value: 0.0261
A3883 PALM_RATPalmParalemmin-121196188p-value: 0.0205
A390C S22A1_RAT37165, Slc22a1Solute carrier family 22 member 121479059p-value: 0.000722
A390C S22A1_RAT37165, Slc22a1Solute carrier family 22 member 121479059p-value: 0.0446
A3923XEXOC8_RATExo84Exocyst complex component 821006903p-value: 0.00249
A393C S22A6_RATOat1, Slc22a6Solute carrier family 22 member 621106686p-value: 0.0000402
A394C S22A7_RATNlt, Oat2Solute carrier family 22 member 721889439p-value: 0.00000619
A4005 TIP_RATCda08, TipT-cell immunomodulatory protein20743259p-value: 0.000151
A4008 MARC2_RATMg87, Mosc2Mitochondrial amidoxime reducing component 221677393p-value: 0.00129
A4042XPP1G_RATPpp1ccSerine/threonine-protein phosphatase PP1-gamma catalytic subunit20773714p-value: 0.0011
A4042XPP1G_RATPpp1ccSerine/threonine-protein phosphatase PP1-gamma catalytic subunit20773714p-value: 0.0171
A4050XS22A5_RATOctn2, LOC303140Solute carrier family 22 member 521858745p-value: 0.0000795
A4050XS22A5_RATOctn2, LOC303140Solute carrier family 22 member 521858745p-value: 0.00098
A409J MBL1_RATMbl1Mannose-binding protein A21588453p-value: 0.00308
A409J MBL1_RATMbl1Mannose-binding protein A21588453p-value: 0.000387
A4123 G0S2_RATG0s2G0/G1 switch protein 221331194p-value: 0.0046
A4123 G0S2_RATG0s2G0/G1 switch protein 221331194p-value: 0.00000354
A421J OASL1_RATOasl2'-5'-oligoadenylate synthase-like protein 121933193p-value: 0.000651
A421J OASL1_RATOasl2'-5'-oligoadenylate synthase-like protein 121933193p-value: 0.000022
A423I SIAT9_RATSiat9, St3gal5Lactosylceramide alpha-220824802p-value: 0.00294
A423I SIAT9_RATSiat9, St3gal5Lactosylceramide alpha-220824802p-value: 0.00211
A424C Q497A2Dsm-1D-serine modulator-121300301p-value: 0.0119
A2848 Z354A_RATZnf354a, Kid1, Tcf17Zinc finger protein 354A21158632p-value: 0.0000167
A2848 Z354A_RATZnf354a, Kid1, Tcf17Zinc finger protein 354A21158632p-value: 0.00117
A4342XHSP74_RATIrp94, Hspa4Heat shock 70 kDa protein 421684418p-value: 0.000857
A4350XHYOU1_RATOrp150, Hyou1Hypoxia up-regulated protein 121642452p-value: 0.0235
A4435 CCG5_RATCacng5Voltage-dependent calcium channel gamma-5 subunit21880495p-value: 0.000159
A4446XCLIC4_RATClic4Chloride intracellular channel protein 422333533p-value: 0.000854
A4506 PLLP_RATPmlp, Tm4sf11Plasmolipin21400970p-value: 0.000246
A4506 PLLP_RATPmlp, Tm4sf11Plasmolipin21400970p-value: 0.000169
A4528 TPC1_RATTpc1, Tpcn1Two pore calcium channel protein 121588056p-value: 0.000269
A4539 TRPV6_RATTrpv6Transient receptor potential cation channel subfamily V member 621856854p-value: 0.000865
A4539 TRPV6_RATTrpv6Transient receptor potential cation channel subfamily V member 621856854p-value: 0.00000671
A454C S6A13_RATGabt2, Gat-2Sodium- and chloride-dependent GABA transporter 221730145p-value: 0.0000166
A454C S6A13_RATGabt2, Gat-2Sodium- and chloride-dependent GABA transporter 221730145p-value: 0.000000306
A4582XARL3_RATArl3ADP-ribosylation factor-like protein 321262167p-value: 0.00184
A4617XG3V7L4Cdh16Protein Cdh1622324225p-value: 0.00011
A464A GTF2I_RATGtf2iGeneral transcription factor II-I22335894p-value: 0.00075
A464A GTF2I_RATGtf2iGeneral transcription factor II-I22335894p-value: 0.0317
A470F BAT1_RATBat1b(0,+)-type amino acid transporter 121509630p-value: 0.00914
A470F BAT1_RATBat1b(0,+)-type amino acid transporter 121509630p-value: 0.00000443
A475C SC5A2_RATSglt2, Slc5a2Sodium/glucose cotransporter 222386465p-value: 0.0000715
A4794 ESPN_RATEspnEspin21269131p-value: 0.0000713
A4801 FAT3_RATFat3Protocadherin Fat 322322981p-value: 0.000169
A4801 FAT3_RATFat3Protocadherin Fat 322322981p-value: 0.000126
A6079XV9GZ80LOC100910868, Cml2Camello-like 221883641p-value: 0.000489
A6079XV9GZ80LOC100910868, Cml2Camello-like 221883641p-value: 0.000000324
A498G FOXM1_RATWin, Foxm1Forkhead box protein M121135721p-value: 0.00187
A5016XODFP2_RATOdf84, Odf2Outer dense fiber protein 222248333p-value: 0.00273
A505C SIL1_RATSil1Nucleotide exchange factor SIL1 ( Precursor)21587750p-value: 0.000829
A505C SIL1_RATSil1Nucleotide exchange factor SIL1 ( Precursor)21587750p-value: 0.00118
A508C SLC31_RATNbatNeutral and basic amino acid transport protein rBAT21458812p-value: 0.00159
A508C SLC31_RATNbatNeutral and basic amino acid transport protein rBAT21458812p-value: 0.000000871
A510C SNP23_RATSnap23Synaptosomal-associated protein 2322156089p-value: 0.000166
A5157 SRPX_RATDrsSushi repeat-containing protein SRPX21234937p-value: 0.00186
A518C SNX16_RATSnx16Sorting nexin-1621363096p-value: 0.0392
A518C SNX16_RATSnx16Sorting nexin-1621363096p-value: 0.00978
A520H NETR_RATPrss12Neurotrypsin21740830p-value: 0.00173
A527F BRE_RATBreBRCA1-A complex subunit BRE22204153p-value: 0.00101
A527F BRE_RATBreBRCA1-A complex subunit BRE22204153p-value: 0.000474
A5281 BZW2_RATBdm2, Hfb2Basic leucine zipper and W2 domain-containing protein 221920240p-value: 0.0000593
A5350 GREM1_RATCktsf1b1, DrmGremlin-121443176p-value: 0.00215
A5350 GREM1_RATCktsf1b1, DrmGremlin-121443176p-value: 0.00156
A5352 HAVR1_RATKim1, Havcr1Hepatitis A virus cellular receptor 1 homolog20780557p-value: 0.00000663
A5352 HAVR1_RATKim1, Havcr1Hepatitis A virus cellular receptor 1 homolog20780557p-value: 0.000000754
A5406XNDRG1_RATNdr1Protein NDRG121942427p-value: 0.00152
A5453 S10AB_RATRGD1563581, LOC100359550Protein S100-A1121579013p-value: 0.00282
A5453 S10AB_RATRGD1563581, LOC100359550Protein S100-A1121579013p-value: 0.0000807
A547A HNF1A_RATHnf-1, Hnf-1aHepatocyte nuclear factor 1-alpha21345838p-value: 0.00105
A547A HNF1A_RATHnf-1, Hnf-1aHepatocyte nuclear factor 1-alpha21345838p-value: 0.000173
A5485XSTRBP_RATStrbpSpermatid perinuclear RNA-binding protein21651232p-value: 0.00404
A5486 STX2_RATEpim, Stx2Syntaxin-221616350p-value: 0.0015
A548A HNF1B_RATHnf-1b, Tcf2Hepatocyte nuclear factor 1-beta21723482p-value: 0.00138
A548A HNF1B_RATHnf-1b, Tcf2Hepatocyte nuclear factor 1-beta21723482p-value: 0.000488
A549A HNF4A_RATHnf-4, Hnf4Hepatocyte nuclear factor 4-alpha21701671p-value: 0.0171
A549A HNF4A_RATHnf-4, Hnf4Hepatocyte nuclear factor 4-alpha21701671p-value: 0.00000286
A5586 RSAD2_RATBest5, Rsad2Radical S-adenosyl methionine domain-containing protein 221787031p-value: 0.00000576
A5621 5NTD_RATNt5, Nte5'-nucleotidase22386800p-value: 0.000571
A5621 5NTD_RATNt5, Nte5'-nucleotidase22386800p-value: 0.000266
A5630XAAAD_RATAada, AadacArylacetamide deacetylase22037443p-value: 0.0000093
A5647XABHEB_RATAbhd14bAlpha/beta hydrolase domain-containing protein 14B21740083p-value: 0.0108
A5647XABHEB_RATAbhd14bAlpha/beta hydrolase domain-containing protein 14B21740083p-value: 0.00000421
A564B PDZ1I_RATMap17, Pdzk1ip1PDZK1-interacting protein 121283841p-value: 0.0213
A564B PDZ1I_RATMap17, Pdzk1ip1PDZK1-interacting protein 121283841p-value: 0.00074
A5651 AOC1_RATAbp1, Aoc1Amiloride-sensitive amine oxidase [copper-containing]22339815p-value: 0.000318
A5651 AOC1_RATAbp1, Aoc1Amiloride-sensitive amine oxidase [copper-containing]22339815p-value: 0.0117
A5657 ACADV_RATVlcad, AcadvlVery long-chain specific acyl-CoA dehydrogenase20707856p-value: 0.0000559
A5663 ACMSD_RATAcmsd2-amino-3-carboxymuconate-6-semialdehyde decarboxylase21589904p-value: 0.0000131
A5663 ACMSD_RATAcmsd2-amino-3-carboxymuconate-6-semialdehyde decarboxylase21589904p-value: 0.0000473
A5684 ACPL2_RATAcpl2Acid phosphatase-like protein 2 ( Precursor)22421466p-value: 0.00461
A5684 ACPL2_RATAcpl2Acid phosphatase-like protein 2 ( Precursor)22421466p-value: 0.00155
A5703 ACY1A_RATAcy1, Acy1bAminoacylase-1A21348483p-value: 0.000273
A5703 ACY1A_RATAcy1, Acy1bAminoacylase-1A21348483p-value: 0.00512
A575H NOX4_RATKox, Nox4NADPH oxidase 421346566p-value: 0.000113
A5788XAMACR_RATAmacrAlpha-methylacyl-CoA racemase21283472p-value: 0.000481
A5788XAMACR_RATAmacrAlpha-methylacyl-CoA racemase21283472p-value: 0.000154
A5800 AMPN_RATAnpepAminopeptidase N20813574p-value: 0.0000185
A5800 AMPN_RATAnpepAminopeptidase N20813574p-value: 0.000388
A5827 ARLY_RATAslArgininosuccinate lyase21464773p-value: 0.00246
A5842 ASSY_RATAssArgininosuccinate synthase21671442p-value: 0.00147
A5842 ASSY_RATAssArgininosuccinate synthase21671442p-value: 0.0000313
A5928XBIEA_RATBlvr, BlvraBiliverdin reductase A21934660p-value: 0.0267
A5928XBIEA_RATBlvr, BlvraBiliverdin reductase A21934660p-value: 0.000016
A5947 BTD_RATBtdBiotinidase21323333p-value: 0.0058
A5947 BTD_RATBtdBiotinidase21323333p-value: 0.0000918
A5948 BUP1_RATBup1, Upb1Beta-ureidopropionase21288312p-value: 0.000361
A5948 BUP1_RATBup1, Upb1Beta-ureidopropionase21288312p-value: 0.00118
A5953 C1TC_RATMthfd, Mthfd1C-1-tetrahydrofolate synthase21380029p-value: 0.000729
A5953 C1TC_RATMthfd, Mthfd1C-1-tetrahydrofolate synthase21380029p-value: 0.0229
A5968 CAH5B_RATCar5bCarbonic anhydrase 5B22308508p-value: 0.00423
A5968 CAH5B_RATCar5bCarbonic anhydrase 5B22308508p-value: 0.00000161
A599B SERC5_RATTpo1, Serinc5Serine incorporator 521785143p-value: 0.00825
A599B SERC5_RATTpo1, Serinc5Serine incorporator 521785143p-value: 0.0169
A6003XCBPD_RATCpdCarboxypeptidase D21557575p-value: 0.00192
A6003XCBPD_RATCpdCarboxypeptidase D21557575p-value: 0.00302
A6012 CBS_RATCbsCystathionine beta-synthase21338265p-value: 0.000758
A6012 CBS_RATCbsCystathionine beta-synthase21338265p-value: 0.0000181
A602I STK3_RATMst2, Stk3Serine/threonine-protein kinase 320908482p-value: 0.00184
A6038 CEGT_RATUgcgCeramide glucosyltransferase22182151p-value: 0.0188
A6038 CEGT_RATUgcgCeramide glucosyltransferase22182151p-value: 0.000202
A603E TOR3A_RATTor3aTorsin-3A22007802p-value: 0.047
A603E TOR3A_RATTor3aTorsin-3A22007802p-value: 0.000116
A6045 CGL_RATCth, CSECystathionine gamma-lyase21250423p-value: 0.011
A6045 CGL_RATCth, CSECystathionine gamma-lyase21250423p-value: 0.000148
A6048XCHDH_RATRRCHDH, ChdhCholine dehydrogenase21143661p-value: 0.00407
A6048XCHDH_RATRRCHDH, ChdhCholine dehydrogenase21143661p-value: 0.00000187
A6049 Q5PQJ8ChfrCheckpoint with forkhead and ring finger domains20788923p-value: 0.0388
A6086 CNDP1_RATCn1Beta-Ala-His dipeptidase22000312p-value: 0.000982
A6086 CNDP1_RATCn1Beta-Ala-His dipeptidase22000312p-value: 0.000369
A6087XCNDP2_RATCndp2Cytosolic non-specific dipeptidase22422125p-value: 0.00000873
A610E O88760AF-9, Mllt3AF-9 protein22034338p-value: 0.000347
A6122 CP26B_RATCyp26b1Cytochrome P450 26B120744053p-value: 0.0437
A6122 CP26B_RATCyp26b1Cytochrome P450 26B120744053p-value: 0.0000101
A6147 CP2CN_RATCyp2c-23, Cyp2c23Cytochrome P450 2C2322361013p-value: 0.00241
A614H NREP_RATP311Neuronal regeneration-related protein21074801p-value: 0.00048
A6184 CP4AC_RATCyp4a-8, Cyp4a8Cytochrome P450 4A1221811381p-value: 0.0409
A6184 CP4AC_RATCyp4a-8, Cyp4a8Cytochrome P450 4A1221811381p-value: 0.0000014
A6213 CRYL1_RATCryLambda-crystallin homolog22103877p-value: 0.0000358
A6213 CRYL1_RATCryLambda-crystallin homolog22103877p-value: 0.0258
A6257 DDC_RATDdcAromatic-L-amino-acid decarboxylase21320606p-value: 0.000435
A6299 DGKG_RATDagk3, DgkgDiacylglycerol kinase gamma21222484p-value: 0.00000729
A6299 DGKG_RATDagk3, DgkgDiacylglycerol kinase gamma21222484p-value: 0.00961
A6321 DHSO_RATSdh1Sorbitol dehydrogenase21852600p-value: 0.0015
A6335 DIAC_RATCtb, CtbsDi-N-acetylchitobiase ( Precursor)21179166p-value: 0.000204
A638B TM110_RATTmem110Transmembrane protein 11020915426p-value: 0.0136
A6403 EBP_RATRsi3-beta-hydroxysteroid-Delta(8)22241910p-value: 0.000307
A643CXTRFE_RATTf, SrprbSerotransferrin21575946p-value: 0.000335
A644I T150A_RATTm6p1, Tmem150Transmembrane protein 150A22211790p-value: 0.00313
A6457 O70177Ces2l, LOC100365112Carboxylesterase21336800p-value: 0.0000261
A6457 O70177Ces2l, LOC100365112Carboxylesterase21336800p-value: 0.000782
A6477 F16P1_RATFbp, Fbp1Fructose-121579012p-value: 0.000355
A6477 F16P1_RATFbp, Fbp1Fructose-121579012p-value: 0.00000142
A6483 FAAA_RATFahFumarylacetoacetase20870798p-value: 0.00575
A6483 FAAA_RATFahFumarylacetoacetase20870798p-value: 0.00000678
A6512 FMO1_RATFmo-1Dimethylaniline monooxygenase [N-oxide-forming] 121539961p-value: 0.00015
A6512 FMO1_RATFmo-1Dimethylaniline monooxygenase [N-oxide-forming] 121539961p-value: 0.0345
A6513XFMO2_RATFmo2Dimethylaniline monooxygenase [N-oxide-forming] 220960767p-value: 0.0027
A6513XFMO2_RATFmo2Dimethylaniline monooxygenase [N-oxide-forming] 220960767p-value: 0.0195
A6515XFMO4_RATFmo4Dimethylaniline monooxygenase [N-oxide-forming] 422320480p-value: 0.0000332
A6515XFMO4_RATFmo4Dimethylaniline monooxygenase [N-oxide-forming] 422320480p-value: 0.00000293
A6527 FTCD_RATFtcdFormimidoyltransferase-cyclodeaminase21655467p-value: 0.000147
A6527 FTCD_RATFtcdFormimidoyltransferase-cyclodeaminase21655467p-value: 0.00175
A6535 FURIN_RATFur, Pcsk3Furin21550633p-value: 0.00464
A653E Q76M99Slc22a19, Slc22a9Organic anion transporter 521934502p-value: 0.0000266
A653E Q76M99Slc22a19, Slc22a9Organic anion transporter 521934502p-value: 0.00000123
A6547XG6PC_RATG6pt, G6pcGlucose-6-phosphatase21592899p-value: 0.00146
A6547XG6PC_RATG6pt, G6pcGlucose-6-phosphatase21592899p-value: 0.00885
A6552 GABT_RATGabat, Abat4-aminobutyrate aminotransferase21418338p-value: 0.0000432
A6552 GABT_RATGabat, Abat4-aminobutyrate aminotransferase21418338p-value: 0.00273
A6559XGALM_RATGalmAldose 1-epimerase21696589p-value: 0.00768
A6559XGALM_RATGalmAldose 1-epimerase21696589p-value: 0.000051
A6572 GATM_RATAgat, GatmGlycine amidinotransferase21929757p-value: 0.0000537
A6572 GATM_RATAgat, GatmGlycine amidinotransferase21929757p-value: 0.00000294
A6605 GLPK_RATGyk, GkGlycerol kinase21089782p-value: 0.0000864
A6605 GLPK_RATGyk, GkGlycerol kinase21089782p-value: 0.000434
A6608 GLT11_RATGalnt11Polypeptide N-acetylgalactosaminyltransferase 1120975415p-value: 0.000128
A6608 GLT11_RATGalnt11Polypeptide N-acetylgalactosaminyltransferase 1120975415p-value: 0.00000422
A6614 GLYAT_RATGlyat, GATF-BGlycine N-acyltransferase21159667p-value: 0.0000283
A6614 GLYAT_RATGlyat, GATF-BGlycine N-acyltransferase21159667p-value: 0.0000037
A6627 GNMT_RATGnmtGlycine N-methyltransferase21909166p-value: 0.00524
A6643 GPX2_RATGpx2Glutathione peroxidase 221421875p-value: 0.000111
A6643 GPX2_RATGpx2Glutathione peroxidase 221421875p-value: 0.000000215
A6663 GSHB_RATGssGlutathione synthetase21394835p-value: 0.0000248
A6664 GSHR_RATGsrGlutathione reductase21692763p-value: 0.0234
A6664 GSHR_RATGsrGlutathione reductase21692763p-value: 0.000149
A6666 GSTA2_RATGsta2, Gsta1Glutathione S-transferase alpha-220979338p-value: 0.000373
A6666 GSTA2_RATGsta2, Gsta1Glutathione S-transferase alpha-220979338p-value: 0.000548
A6688 HAOX2_RATHao3, Haox2Hydroxyacid oxidase 221901261p-value: 0.0000245
A6688 HAOX2_RATHao3, Haox2Hydroxyacid oxidase 221901261p-value: 0.0004
A6710XHEM2_RATAladDelta-aminolevulinic acid dehydratase22110162p-value: 0.000322
A6710XHEM2_RATAladDelta-aminolevulinic acid dehydratase22110162p-value: 0.0107
A6716 HEPS_RATHpnSerine protease hepsin21390672p-value: 0.00548
A6716 HEPS_RATHpnSerine protease hepsin21390672p-value: 0.000018
A672C VAMP5_RATVamp5Vesicle-associated membrane protein 521157555p-value: 0.00484
A6737 HNMT_RATHnmtHistamine N-methyltransferase21331503p-value: 0.000152
A6737 HNMT_RATHnmtHistamine N-methyltransferase21331503p-value: 0.00000258
A6741 HPPD_RATHpd4-hydroxyphenylpyruvate dioxygenase21347308p-value: 0.00703
A6813 IVD_RATIvdIsovaleryl-CoA dehydrogenase21750166p-value: 0.0135
A6813 IVD_RATIvdIsovaleryl-CoA dehydrogenase21750166p-value: 0.00000259
A681CXVIGLN_RATHbp, HdlbpVigilin20918483p-value: 0.00473
A6825XKAD4_RATAk3l1, Ak4Adenylate kinase 421861648p-value: 0.0000612
A6825XKAD4_RATAk3l1, Ak4Adenylate kinase 421861648p-value: 0.00000125
A6847 KEG1_RATHp33Glycine N-acyltransferase-like protein Keg121571495p-value: 0.0000261
A6876 KYNU_RATKynuKynureninase21800437p-value: 0.0000144
A6876 KYNU_RATKynuKynureninase21800437p-value: 0.0000868
A687B Q6AYE0Tmbim1Protein Tmbim122079463p-value: 0.00000476
A687B Q6AYE0Tmbim1Protein Tmbim122079463p-value: 0.00135
A6893 LIAS_RATLiasLipoyl synthase21348242p-value: 0.0000557
A6940XM2GD_RATDmgdhDimethylglycine dehydrogenase20713880p-value: 0.00165
A6940XM2GD_RATDmgdhDimethylglycine dehydrogenase20713880p-value: 0.000358
A6977 MBOA5_RATGrcc3f, Mboat5Lysophospholipid acyltransferase 522069418p-value: 0.00121
A6979 MBTP1_RATS1p, Ski1Membrane-bound transcription factor site-1 protease21422292p-value: 0.00391
A6979 MBTP1_RATS1p, Ski1Membrane-bound transcription factor site-1 protease21422292p-value: 0.00133
A7010 METK2_RATAms2, LOC100363915S-adenosylmethionine synthase isoform type-221445584p-value: 0.0000133
A7016 MGAT1_RATGnt1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase21845128p-value: 0.00134
A7029 MIOX_RATAldrl6, Ksp32Inositol oxygenase21353338p-value: 0.0000312
A7029 MIOX_RATAldrl6, Ksp32Inositol oxygenase21353338p-value: 0.0054
A702C VPS52_RATAre1, Sacm2lVacuolar protein sorting-associated protein 52 homolog21466035p-value: 0.0103
A7030 MIPEP_RATMip, MipepMitochondrial intermediate peptidase20908570p-value: 0.00055
A7030 MIPEP_RATMip, MipepMitochondrial intermediate peptidase20908570p-value: 0.000162
A7051 MMSA_RATMmsdh, Aldh6a1Methylmalonate-semialdehyde dehydrogenase [acylating]20708753p-value: 0.00373
A7051 MMSA_RATMmsdh, Aldh6a1Methylmalonate-semialdehyde dehydrogenase [acylating]20708753p-value: 0.0000302
A7059 MP2K5_RATMek5, Mkk5Dual specificity mitogen-activated protein kinase kinase 521351778p-value: 0.00236
A705F CD123_RATD123, Cdc123Cell division cycle protein 123 homolog21150398p-value: 0.00167
A7064 MSRA_RATMsraMitochondrial peptide methionine sulfoxide reductase21486630p-value: 0.00106
A7064 MSRA_RATMsraMitochondrial peptide methionine sulfoxide reductase21486630p-value: 0.0000704
A7102 NADC_RATQprtNicotinate-nucleotide pyrophosphorylase [carboxylating]21987713p-value: 0.00283
A7102 NADC_RATQprtNicotinate-nucleotide pyrophosphorylase [carboxylating]21987713p-value: 0.00664
A710I TBC14_RATTbc1d14TBC1 domain family member 1421711000p-value: 0.000217
A7111 Q9QX71napNapsin20789453p-value: 0.00647
A7111 Q9QX71napNapsin20789453p-value: 0.000161
A7140XQ5XIH3Ndufv1NADH dehydrogenase (Ubiquinone) flavoprotein 121978473p-value: 0.0113
A7154 NEUR2_RATNeu2Sialidase-221591663p-value: 0.00021
A7156XNFS1_RATNifs, Nfs1Cysteine desulfurase22064871p-value: 0.00708
A7156XNFS1_RATNifs, Nfs1Cysteine desulfurase22064871p-value: 0.00534
A7175 NQO2_RATNqo2Ribosyldihydronicotinamide dehydrogenase [quinone]20816559p-value: 0.0000401
A7175 NQO2_RATNqo2Ribosyldihydronicotinamide dehydrogenase [quinone]20816559p-value: 0.00579
A718C YLAT1_RATSlc7a7Y+L amino acid transporter 120879733p-value: 0.0000752
A7223 OAT_RATOatOrnithine aminotransferase21894364p-value: 0.0019
A7223 OAT_RATOatOrnithine aminotransferase21894364p-value: 2.43E-09
A7299 PARG_RATPargPoly(ADP-ribose) glycohydrolase21567614p-value: 0.00041
A7344XPDK2_RATPdk2[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 221558654p-value: 0.0093
A7344XPDK2_RATPdk2[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 221558654p-value: 0.000828
A7347 PDP1_RATPpm2c, Pdp1[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 121013206p-value: 0.00808
A7347 PDP1_RATPpm2c, Pdp1[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 121013206p-value: 0.0012
A7348 PDP2_RATPdp2[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 222423766p-value: 0.000274
A7357XPEPD_RATPepdXaa-Pro dipeptidase22059436p-value: 0.0000453
A7357XPEPD_RATPepdXaa-Pro dipeptidase22059436p-value: 0.0191
A7367 CBPQ_RATPgcpCarboxypeptidase Q21761156p-value: 0.0000293
A7367 CBPQ_RATPgcpCarboxypeptidase Q21761156p-value: 0.000164
A7383 PH4H_RATPahPhenylalanine-4-hydroxylase21452072p-value: 0.0000561
A7387 PHLP1_RATPhlpp, Plekhe1PH domain leucine-rich repeat protein phosphatase 121172268p-value: 0.000894
A7447 PNCB_RATNaprt1Nicotinate phosphoribosyltransferase21477983p-value: 0.000129
A7451 PNPO_RATPnpoPyridoxine-5'-phosphate oxidase21507033p-value: 0.00064
A7481 Q6AYS3Ppgb, CtsaProtective protein for beta-galactosidase21260178p-value: 0.000644
A7515 PRSS8_RATPrss8Prostasin21705327p-value: 0.00029
A7515 PRSS8_RATPrss8Prostasin21705327p-value: 0.000438
A7551XPTPS_RATPts6-pyruvoyl tetrahydrobiopterin synthase21543175p-value: 0.00209
A7605 Q8K3R0Ces6, LOC246252Carboxylesterase isoenzyme21276612p-value: 0.0298
A760B YIPF3_RATYipf3Protein YIPF321140114p-value: 0.000219
A7681 RGN_RATSmp30Regucalcin21279172p-value: 0.000101
A7681 RGN_RATSmp30Regucalcin21279172p-value: 0.000000235
A7693 RISC_RATRisc, Scpep1Retinoid-inducible serine carboxypeptidase22355113p-value: 0.00668
A7693 RISC_RATRisc, Scpep1Retinoid-inducible serine carboxypeptidase22355113p-value: 0.000124
A7766 S27A1_RATFatp, Fatp1Long-chain fatty acid transport protein 121493560p-value: 0.0193
A7767 S27A2_RATAcsvl1, Facvl1Very long-chain acyl-CoA synthetase22323350p-value: 0.000961
A7767 S27A2_RATAcsvl1, Facvl1Very long-chain acyl-CoA synthetase22323350p-value: 0.000798
A777BXQ5FVL8Abcb10ATP-binding cassette22058800p-value: 0.00487
A777BXQ5FVL8Abcb10ATP-binding cassette22058800p-value: 0.0307
A7781 SCLY_RATSclySelenocysteine lyase21987331p-value: 0.0031
A7781 SCLY_RATSclySelenocysteine lyase21987331p-value: 0.000263
A7788 SDHL_RATSdsL-serine dehydratase/L-threonine deaminase21926749p-value: 0.000498
A7795 Q80YG1Psat1Phosphoserine aminotransferase21584564p-value: 0.000301
A7795 Q80YG1Psat1Phosphoserine aminotransferase21584564p-value: 0.0000146
A7813 SIA7C_RATSiat7c, St6galnac3Alpha-N-acetylgalactosaminide alpha-222349842p-value: 0.0000507
A7843XSODE_RATSod-3Extracellular superoxide dismutase [Cu-Zn]21699852p-value: 0.000333
A7843XSODE_RATSod-3Extracellular superoxide dismutase [Cu-Zn]21699852p-value: 0.0037
A784G HOMEZ_RATHomezHomeobox and leucine zipper protein Homez21372063p-value: 0.0066
A7878 ST1B1_RATSt1b1Sulfotransferase family cytosolic 1B member 122204253p-value: 0.0000697
A7879 ST1C2_RATSultk1, RGD1562392Sulfotransferase 1C220884839p-value: 0.000149
A7879 ST1C2_RATSultk1, RGD1562392Sulfotransferase 1C220884839p-value: 0.00456
A7904 SUOX_RATSuoxSulfite oxidase22112801p-value: 0.000328
A7984 THTR_RATTstThiosulfate sulfurtransferase21085824p-value: 0.000527
A7984 THTR_RATTstThiosulfate sulfurtransferase21085824p-value: 0.00154
A8048 TRXR2_RATTrxr2, Txnrd2Thioredoxin reductase 221467109p-value: 0.000443
A808G HTF4_RATTcf12Transcription factor 1222390291p-value: 0.00179
A8160 UDB15_RATUgt2b15, Ugt2b12, Ugt2b36UDP-glucuronosyltransferase 2B1521107485p-value: 0.0000389
A8160 UDB15_RATUgt2b15, Ugt2b12, Ugt2b36UDP-glucuronosyltransferase 2B1521107485p-value: 0.000614
A8165 UGDH_RATUgdhUDP-glucose 6-dehydrogenase22216866p-value: 0.00201
A824B AQP1_RATChip28Aquaporin-121450146p-value: 0.0232
A824B AQP1_RATChip28Aquaporin-121450146p-value: 0.0000265
A829B AQP7_RATAqp7Aquaporin-721946904p-value: 0.0000359
A8378XQ68FT8Serpinf2Protein Serpinf221490913p-value: 0.00331
A8378XQ68FT8Serpinf2Protein Serpinf221490913p-value: 0.000000855
A8384XQ7TPI9Serpinc1Ac2-24821341870p-value: 0.00186
A8384XQ7TPI9Serpinc1Ac2-24821341870p-value: 0.000104
A8408 Q498U6Dffa, ICAD-SDNAation factor21411143p-value: 0.0278
A8413 GPC3_RATGpc3, OCI-5Glypican-321401787p-value: 0.000682
A843H PIM3_RATKid1, Pim3Serine/threonine-protein kinase pim-321426517p-value: 0.00251
A846B Q6AY58Bcap31B-cell receptor-associated protein 3121564098p-value: 0.000519
A848G Q6MG182310ex4-5, 2331ex4-5Immediate early response 321590666p-value: 0.0000266
A8644 2ABD_RATPpp2r2dSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform21089421p-value: 0.00077
A8714 CK5P1_RATCdk5rap1CDK5 regulatory subunit-associated protein 122420477p-value: 0.024
A8714 CK5P1_RATCdk5rap1CDK5 regulatory subunit-associated protein 122420477p-value: 0.000131
A8735 CRYM_RATCrymKetimine reductase mu-crystallin21100235p-value: 0.000749
A8735 CRYM_RATCrymKetimine reductase mu-crystallin21100235p-value: 0.00863
A877A PRGC2_RATPerc, Pgc1Peroxisome proliferator-activated receptor gamma coactivator 1-beta22069433p-value: 0.0014
A877A PRGC2_RATPerc, Pgc1Peroxisome proliferator-activated receptor gamma coactivator 1-beta22069433p-value: 0.015
A8816 GNL3_RATNs, Gnl3Guanine nucleotide-binding protein-like 321078372p-value: 0.000978
A8816 GNL3_RATNs, Gnl3Guanine nucleotide-binding protein-like 321078372p-value: 0.00193
A8825 GUC2A_RATGuca2Guanylin21136726p-value: 0.000000312
A8826 GUC2B_RATGuca2bGuanylate cyclase activator 2B22291148p-value: 0.000121
A8855 LAMP2_RATLamp-2, Lamp2Lysosome-associated membrane glycoprotein 222115097p-value: 0.0000168
A8979 PXK_RATPxkPX domain-containing protein kinase-like protein21622626p-value: 0.00245
A8979 PXK_RATPxkPX domain-containing protein kinase-like protein21622626p-value: 0.00213
A8999 REBL1_RATRhebl1GTPase RhebL121692077p-value: 0.000104
A9049XSH24A_RATSh2d4aSH2 domain-containing protein 4A22193807p-value: 0.00372
A9111 Q80Z88Tlr3Toll-like receptor 3 ( Fragment)22178634p-value: 0.000578
A9149XVTDB_RATDbp, GcVitamin D-binding protein22338890p-value: 0.00098
A9149XVTDB_RATDbp, GcVitamin D-binding protein22338890p-value: 0.00000288
A919GXIOD1_RATItdi1, Txdi1Type I iodothyronine deiodinase21920936p-value: 0.00000338
A919GXIOD1_RATItdi1, Txdi1Type I iodothyronine deiodinase21920936p-value: 0.00151
A923H PP14C_RATKepiProtein phosphatase 1 regulatory subunit 14C21167150p-value: 0.000864
A924G Q6YH22PkigProtein Pkig21620597p-value: 0.00243
A924G Q6YH22PkigProtein Pkig21620597p-value: 0.00117
A925BXCUBN_RATIfcr, CubnCubilin22142611p-value: 0.000102
A925BXCUBN_RATIfcr, CubnCubilin22142611p-value: 0.000000187
A930K AMBN_RATAmbnAmeloblastin21336093p-value: 0.00674
A9311 O35977GDNFR-beta, RETL2Glial cell line derived neurotrophic factor family receptor alpha 221398174p-value: 0.0000801
A938G IRF1_RATIrf1Interferon regulatory factor 121928864p-value: 0.0000762
A938G IRF1_RATIrf1Interferon regulatory factor 121928864p-value: 0.00222
A941J D3ZQT3Olr486_predictedOlfactory receptor22288423p-value: 0.0115
A9426 OLR1_RATLox1, Oldlr1Oxidized low-density lipoprotein receptor 121661173p-value: 0.00000495
A9426 OLR1_RATLox1, Oldlr1Oxidized low-density lipoprotein receptor 121661173p-value: 0.0142
A944B DYLT1_RATTctel1, Tctex-1Dynein light chain Tctex-type 122064750p-value: 0.000869
A944B DYLT1_RATTctel1, Tctex-1Dynein light chain Tctex-type 122064750p-value: 0.000359
A9457 PTH1R_RATPthr, Pthr1Parathyroid hormone/parathyroid hormone-related peptide receptor21188572p-value: 0.0000254
A9457 PTH1R_RATPthr, Pthr1Parathyroid hormone/parathyroid hormone-related peptide receptor21188572p-value: 0.000801
A948B EAA3_RATEaac1, Eaat3Excitatory amino acid transporter 320764410p-value: 0.0000165
A948B EAA3_RATEaac1, Eaat3Excitatory amino acid transporter 320764410p-value: 0.0113
A949G Q5RJP5Isg20Interferon stimulated exonuclease 2021812751p-value: 0.000000306
A949G Q5RJP5Isg20Interferon stimulated exonuclease 2021812751p-value: 0.00000025
A9521 UNC5C_RATUnc5h3, Unc5cNetrin receptor UNC5C21888770p-value: 0.00213
A956H PRLR_RATPrlrProlactin receptor22004562p-value: 0.00121
A956H PRLR_RATPrlrProlactin receptor22004562p-value: 0.0000138
A962B ETFB_RATEtfbElectron transfer flavoprotein subunit beta20765556p-value: 0.00785
A966B EXOC6_RATSec15, Sec15aExocyst complex component 621141288p-value: 0.000402
A966B EXOC6_RATSec15, Sec15aExocyst complex component 621141288p-value: 0.0000474
A9732 NHRF3_RATClamp, Diphor1Na(+)/H(+) exchange regulatory cofactor NHE-RF321270725p-value: 0.000288
A9732 NHRF3_RATClamp, Diphor1Na(+)/H(+) exchange regulatory cofactor NHE-RF321270725p-value: 0.0101
A9747 SCLT1_RATSap1Sodium channel and clathrin linker 122119392p-value: 0.0143
A9747 SCLT1_RATSap1Sodium channel and clathrin linker 122119392p-value: 0.025
A9817 CCL20_RATScya20, St38C-C motif chemokine 2021035433p-value: 0.00000263
A9817 CCL20_RATScya20, St38C-C motif chemokine 2021035433p-value: 0.00000141
A9831 CD82_RATKai1, Cd82CD82 antigen21219376p-value: 0.00686
A988A SCAF8_RATRbm16, Scaf8Protein SCAF822424556p-value: 0.0048
A988B G3V8M6Folr1Folate receptor 1 (Adult)21517481p-value: 0.00148
A988B G3V8M6Folr1Folate receptor 1 (Adult)21517481p-value: 0.0000186
A9903 FAF1_RATFaf1FAS-associated factor 122420042p-value: 0.0148
A9903 FAF1_RATFaf1FAS-associated factor 122420042p-value: 0.000165
A9910 FGF9_RATFgf-9Fibroblast growth factor 921518483p-value: 0.00551
A9910 FGF9_RATFgf-9Fibroblast growth factor 921518483p-value: 0.0323
A994B Q6IRK4Slc37a4Protein Slc37a422146943p-value: 0.000015
A994B Q6IRK4Slc37a4Protein Slc37a422146943p-value: 0.000581
A9979 LSHB_RATTLHB2, LhbLutropin subunit beta22109907p-value: 0.0181
A9987 MACD1_RATLrp16, Macrod1O-acetyl-ADP-ribose deacetylase MACROD121800848p-value: 0.00025
A9987 MACD1_RATLrp16, Macrod1O-acetyl-ADP-ribose deacetylase MACROD121800848p-value: 0.00132
A7978 THIKA_RATAcaa1a3-ketoacyl-CoA thiolase A20903684p-value: 0.00119
Olr1226  Olr1226olfactory receptor 122621993874p-value: 0.000865
OLR469_PREDICTED  Olr469_predictedolfactory receptor 469 (predicted)20864673p-value: 0.00265
RGD1359713  RGD1359713hypothetical RNA binding protein RGD135971320911911p-value: 0.000402
LOC246263  LOC246263kidney-specific protein (KS)20927977p-value: 0.0000405
LOC246263  LOC246263kidney-specific protein (KS)20927977p-value: 0.0175
OLR62_PREDICTED  Olr62_predictedolfactory receptor 62 (predicted)21124067p-value: 0.000801
RT1-CE14  RT1-CE14, RT1-CE1, RT1-CE12RT1 class I, CE14, RT1 class I, CE1, RT1 class I, CE1221409488p-value: 0.000313
LOC361914  LOC361914, Slc7a12similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12, solute carrier family 7 (cationic amino acid transporter, y+ system), member 1221431536p-value: 0.000765
LOC361914  LOC361914, Slc7a12similar to solute carrier family 7 (cationic amino acid transporter, y+ system), member 12, solute carrier family 7 (cationic amino acid transporter, y+ system), member 1221431536p-value: 2.50E-09
RGD1303232  RGD1303232Phytn_dehydro and Pyr_redox domain containing protein RGD130323221520252p-value: 0.00186
RGD1303232  RGD1303232Phytn_dehydro and Pyr_redox domain containing protein RGD130323221520252p-value: 0.0000021
DDOST_PREDICTED  Ddost_predicteddolichyl-di-phosphooligosaccharide-protein glycotransferase (predicted)21875100p-value: 0.000904
MGC105830  MGC105830similar to Ras-related protein Rab-1B22035126p-value: 0.0019
RGD1311980  RGD1311980similar to cDNA sequence BC00404422308872p-value: 0.000328
RGD1311980  RGD1311980similar to cDNA sequence BC00404422308872p-value: 0.000412
MGC95092  MGC95092similar to phospholysine phosphohistidine inorganic pyrophosphate phosphata (5M590)22320018p-value: 0.0142
MGC95092  MGC95092similar to phospholysine phosphohistidine inorganic pyrophosphate phosphata (5M590)22320018p-value: 0.000293
HSPA1B  Hspa1b, Hspa1aheat shock 70kD protein 1B (mapped), heat shock 70kD protein 1A22357696p-value: 0.0000467
HSPA1B  Hspa1b, Hspa1aheat shock 70kD protein 1B (mapped), heat shock 70kD protein 1A22357696p-value: 0.000000415

Compile date 08-10-2018© iMODE-CKD consortium