CKDdb-logoCKDdb - Molecule ID BK023

geneBBC3, PUMA
namePUMA/JFY1 protein
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BBC3_HUMANQ9BXH1ENSG0000010532727113Hs.467020605854

Functions and classifications

GOC:cytosol, C:mitochondrial outer membrane, P:activation of cysteine-type endopeptidase activity involved in apoptotic process, P:apoptotic signaling pathway, P:cellular response to DNA damage stimulus, P:cellular response to hypoxia, P:determination of adult lifespan, P:execution phase of apoptosis, P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, P:negative regulation of endoplasmic reticulum calcium ion concentration, P:negative regulation of growth, P:positive regulation of intrinsic apoptotic signaling pathway, P:positive regulation of neuron apoptotic process, P:positive regulation of protein homooligomerization, P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, P:positive regulation of release of cytochrome c from mitochondria, P:positive regulation of thymocyte apoptotic process, P:release of cytochrome c from mitochondria, P:release of sequestered calcium ion into cytosol, C:mitochondrion, P:apoptotic process, P:induction of apoptosis, P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, P:reduction of endoplasmic reticulum calcium ion concentration
UniProt3D-structure, Alternative splicing, Apoptosis, Complete proteome, Mitochondrion, Reference proteome
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.390.0000241RNA microarray19698090
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.399.53E-04RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.452.05E-04RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.004374RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium