CKDdb-logoCKDdb - Molecule ID B1962

geneCARD8, NDPP1, TUCAN
nameCaspase recruitment domain protein 8
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CARD8_HUMANQ9Y2G2ENSG0000010548322900Hs.446146609051

Functions and classifications

GOC:cytoplasm, C:NLRP3 inflammasome complex, C:nucleus, F:cysteine-type endopeptidase activator activity involved in apoptotic process, F:protein homodimerization activity, P:interleukin-1 alpha production, P:interleukin-1 beta production, P:negative regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of interleukin-1 beta secretion, P:protein catabolic process, P:pyroptosis, C:intracellular, P:regulation of apoptotic process, P:negative regulation of I-kappaB kinase/NF-kappaB cascade
UniProt3D-structure, Alternative splicing, Apoptosis, Complete proteome, Cytoplasm, Nucleus, Polymorphism, Reference proteome
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.450.0000486RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.29< 0.05RNA microarray21752957

Compile date 08-10-2018© iMODE-CKD consortium