CKDdb-logoCKDdb - Molecule ID B0129

geneAPOBEC3G, MDS019
nameDNA dC->dU-editing enzyme APOBEC-3G
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABC3G_HUMANQ9HC16ENSG0000023971360489Hs.660143607113

Functions and classifications

GOC:apolipoprotein B mRNA editing enzyme complex, C:cytoplasmic mRNA processing body, C:cytosol, C:mitochondrion, F:cytidine deaminase activity, F:deoxycytidine deaminase activity, F:protein homodimerization activity, F:RNA binding, F:zinc ion binding, P:base conversion or substitution editing, P:defense response to virus, P:DNA cytosine deamination, P:innate immune response, P:negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, P:negative regulation of transposition, P:positive regulation of defense response to virus by host, P:viral process, F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, P:metabolic process, F:metal ion binding, P:negative regulation of retroviral genome replication, P:viral reproduction, P:virus-host interaction, F:zinc ion binding, F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, P:metabolic process
UniProt3D-structure, Alternative splicing, Antiviral defense, Complete proteome, Cytoplasm, Host-virus interaction, Hydrolase, Immunity, Innate immunity, Metal-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Ubl conjugation, Zinc, Lipoprotein
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.000144RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.343.23E-06RNA microarray20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.29< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)18.26< 0.05RNA microarray21752957

Compile date 08-10-2018© iMODE-CKD consortium