CKDdb-logoCKDdb - Molecule ID A9799

geneBMP7, OP1
nameBone morphogenetic protein 7 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BMP7_HUMANP18075ENSG00000101144655Hs.473163112267

Functions and classifications

GOC:extracellular matrix, C:extracellular space, C:membrane-bounded vesicle, F:heparin binding, P:axon guidance, P:BMP signaling pathway, P:branching involved in salivary gland morphogenesis, P:branching morphogenesis of an epithelial tube, P:cartilage development, P:cellular response to hypoxia, P:dendrite development, P:embryonic camera-type eye morphogenesis, P:embryonic limb morphogenesis, P:embryonic pattern specification, P:embryonic skeletal joint morphogenesis, P:epithelial cell differentiation, P:epithelial to mesenchymal transition, P:extracellular matrix organization, P:growth, P:mesoderm formation, P:mesonephros development, P:metanephric mesenchymal cell proliferation involved in metanephros development, P:metanephric mesenchyme morphogenesis, P:metanephros development, P:monocyte aggregation, P:negative regulation of glomerular mesangial cell proliferation, P:negative regulation of MAP kinase activity, P:negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis, P:negative regulation of mitosis, P:negative regulation of neurogenesis, P:negative regulation of neuron differentiation, P:negative regulation of NF-kappaB import into nucleus, P:negative regulation of NF-kappaB transcription factor activity, P:negative regulation of Notch signaling pathway, P:negative regulation of prostatic bud formation, P:negative regulation of striated muscle cell apoptotic process, P:negative regulation of transcription, DNA-templated, P:nephrogenic mesenchyme morphogenesis, P:neuron projection morphogenesis, P:odontogenesis of dentin-containing tooth, P:ossification, P:positive regulation of apoptotic process, P:positive regulation of bone mineralization, P:positive regulation of dendrite development, P:positive regulation of heterotypic cell-cell adhesion, P:positive regulation of hyaluranon cable assembly, P:positive regulation of neuron differentiation, P:positive regulation of osteoblast differentiation, P:positive regulation of pathway-restricted SMAD protein phosphorylation, P:positive regulation of peptidyl-threonine phosphorylation, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of transcription, DNA-templated, P:protein localization to nucleus, P:regulation of branching involved in prostate gland morphogenesis, P:regulation of removal of superoxide radicals, P:response to estradiol, P:response to peptide hormone, P:response to vitamin D, P:skeletal system development, P:SMAD protein signal transduction, P:steroid hormone mediated signaling pathway, P:ureteric bud development, C:extracellular region, C:extracellular matrix, P:negative regulation of cell proliferation, P:regulation of phosphorylation, P:ureteric bud development, C:extracellular space, P:branching morphogenesis of a tube, P:negative regulation of transcription, DNA-dependent, P:pathway-restricted SMAD protein phosphorylation, P:positive regulation of transcription, DNA-dependent
UniProt3D-structure, Chondrogenesis, Complete proteome, Cytokine, Developmental protein, Differentiation, Direct protein sequencing, Disulfide bond, Glycoprotein, Growth factor, Osteogenesis, Pharmaceutical, Polymorphism, Reference proteome, Secreted, Signal
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17095863Homo sapiens10urinewholeChronic_Renal_Insufficiency (Chronic kidney disease)0.69 Antibody Array17095863
Exp17183245Homo sapiens24kidneyproximal tubuleproteinuria (proteinuric nephropathies)18.13< 0.05cDNA microarrays17183245
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.290.000053RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.00688RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.340.000986RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.33< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.05< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.09< 0.05RNA microarray21752957

Compile date 08-10-2018© iMODE-CKD consortium