CKDdb-logoCKDdb - Molecule ID A9789

geneBDNF, BDNF 2-5, BDNF 1-5
nameBrain-derived neurotrophic factor precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BDNF_HUMANP23560ENSG00000176697627Hs.502182113505, 209880, 610269, 612469

Functions and classifications

GOC:extracellular region, C:perinuclear region of cytoplasm, C:synaptic vesicle, F:growth factor activity, P:axon guidance, P:axon target recognition, P:behavioral fear response, P:chronic inflammatory response, P:dendrite development, P:feeding behavior, P:glutamate secretion, P:inner ear development, P:learning or memory, P:mechanoreceptor differentiation, P:mitochondrial electron transport, NADH to ubiquinone, P:negative regulation of neuroblast proliferation, P:negative regulation of neuron apoptotic process, P:negative regulation of striated muscle tissue development, P:nerve development, P:nervous system development, P:neuron recognition, P:positive regulation of long-term neuronal synaptic plasticity, P:positive regulation of neuron differentiation, P:positive regulation of synapse assembly, P:regulation of excitatory postsynaptic membrane potential, P:regulation of metabolic process, P:regulation of retinal cell programmed cell death, P:regulation of short-term neuronal synaptic plasticity, P:response to anesthetic, P:response to fluoxetine, P:response to hormone, P:response to hyperoxia, P:response to hypoxia, P:response to vitamin A, P:ureteric bud development, "C:perinuclear region of cytoplasm, C:cytoplasmic membrane-bounded vesicle, P:fear response, P:regulation of synaptic plasticity, P:response to drug
UniProt3D-structure, Alternative promoter usage, Alternative splicing, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Growth factor, Polymorphism, Reference proteome, Secreted, Signal
PADBSIG: signalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.315.91E-04RNA microarray26317775
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.325.22E-04RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium