CKDdb-logoCKDdb - Molecule ID A9691

geneCAV3
nameCaveolin-3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CAV3_HUMANP56539ENSG00000182533859Hs.98303123320, 192600, 272120, 601253, 606072, 607801, 611818, 614321

Functions and classifications

GOC:caveola, C:cell surface, C:dystrophin-associated glycoprotein complex, C:endoplasmic reticulum, C:Golgi membrane, C:membrane raft, C:neuromuscular junction, C:T-tubule, C:vesicle, F:calcium channel regulator activity, F:connexin binding, F:potassium channel inhibitor activity, F:protein C-terminus binding, F:protein complex binding, F:protein complex scaffold, F:sodium channel regulator activity, P:actin filament organization, P:cardiac muscle cell development, P:caveola assembly, P:cell growth, P:cholesterol homeostasis, P:cytoplasmic microtubule organization, P:establishment of protein localization to plasma membrane, P:glucose homeostasis, P:heart trabecula formation, P:muscle cell cellular homeostasis, P:muscle organ development, P:myoblast fusion, P:negative regulation of calcium ion transport, P:negative regulation of cardiac muscle hypertrophy, P:negative regulation of cell growth involved in cardiac muscle cell development, P:negative regulation of cell size, P:negative regulation of MAP kinase activity, P:negative regulation of nitric-oxide synthase activity, P:negative regulation of potassium ion transmembrane transport, P:negative regulation of potassium ion transmembrane transporter activity, P:negative regulation of protein localization to cell surface, P:negative regulation of sarcomere organization, P:nucleus localization, P:plasma membrane repair, P:positive regulation of caveolin-mediated endocytosis, P:positive regulation of cell proliferation, P:positive regulation of cytosolic calcium ion concentration, P:positive regulation of microtubule polymerization, P:positive regulation of myotube differentiation, P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process, P:protein localization to plasma membrane, P:regulation of branching involved in mammary gland duct morphogenesis, P:regulation of calcium ion import, P:regulation of calcium ion transmembrane transporter activity, P:regulation of heart rate, P:regulation of membrane depolarization involved in regulation of cardiac muscle cell action potential, P:regulation of nerve growth factor receptor activity, P:regulation of p38MAPK cascade, P:regulation of protein kinase B signaling, P:regulation of signal transduction by receptor internalization, P:regulation of skeletal muscle contraction, P:regulation of sodium ion transmembrane transporter activity, P:regulation of transforming growth factor beta receptor signaling pathway, P:regulation of ventricular cardiac muscle cell action potential, P:regulation of ventricular cardiac muscle cell membrane depolarization, P:regulation of ventricular cardiac muscle cell membrane repolarization, P:T-tubule organization, P:triglyceride metabolic process, C:Z disc, P:elevation of cytosolic calcium ion concentration, P:muscle cell homeostasis, P:regulation of cardiac muscle contraction
UniProtCardiomyopathy, Cell membrane, Complete proteome, Disease mutation, Golgi apparatus, Isopeptide bond, Limb-girdle muscular dystrophy, Long QT syndrome, Membrane, Polymorphism, Reference proteome, Ubl conjugation
PADBscaffolder, docking, adaptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.420.00422RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium