CKDdb-logoCKDdb - Molecule ID A9435

geneADCYAP1R1
namePituitary adenylate cyclase activating polypeptide type I receptor precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PACR_HUMANP41586ENSG00000078549117Hs.377783102981

Functions and classifications

GOC:caveola, C:cell surface, C:endosome, C:integral component of plasma membrane, C:neuron projection, C:rough endoplasmic reticulum, C:tight junction, F:neuropeptide binding, F:receptor activity, F:vasoactive intestinal polypeptide receptor activity, P:activation of adenylate cyclase activity, P:activation of phospholipase C activity, P:cAMP-mediated signaling, P:cell differentiation, P:development of primary female sexual characteristics, P:multicellular organismal response to stress, P:negative regulation of cell death, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of calcium ion transport into cytosol, P:positive regulation of inositol phosphate biosynthetic process, P:response to drug, P:response to estradiol, P:response to ethanol, P:spermatogenesis, C:integral component of membrane, F:G-protein coupled receptor activity, C:plasma membrane, P:positive regulation of cAMP biosynthetic process, C:Golgi membrane, C:integral to plasma membrane, F:pituitary adenylate cyclase-activating polypeptide receptor activity, P:nerve growth factor receptor signaling pathway, P:response to estradiol stimulus, C:integral to membrane
UniProt3D-structure, Alternative splicing, Cell membrane, Complete proteome, Developmental protein, Differentiation, Disulfide bond, G-protein coupled receptor, Glycoprotein, Membrane, Receptor, Reference proteome, Signal, Spermatogenesis, Transducer, Transmembrane, Transmembrane helix
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.260.000901RNA microarray19698090
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.22< 0.05RNA-seq23757392
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.049762673LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)3.474.09E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium