CKDdb-logoCKDdb - Molecule ID A9257

geneC3AR1, AZ3B, C3R1
nameC3a anaphylatoxin chemotactic receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
C3AR_HUMANQ16581ENSG00000171860719Hs.591148605246

Functions and classifications

GOC:integral component of plasma membrane, F:C3a anaphylatoxin receptor activity, F:complement component C3a receptor activity, F:N-formyl peptide receptor activity, F:phosphatidylinositol phospholipase C activity, P:blood circulation, P:chemotaxis, P:inflammatory response, P:positive regulation of angiogenesis, P:positive regulation of cytosolic calcium ion concentration, P:positive regulation of macrophage chemotaxis, P:positive regulation of neutrophil chemotaxis, P:positive regulation vascular endothelial growth factor production, C:integral component of membrane, C:integral to plasma membrane, P:elevation of cytosolic calcium ion concentration, P:regulation of blood pressure, P:tolerance induction to nonself antigen, C:integral to membrane, C:plasma membrane, P:complement receptor mediated signaling pathway
UniProtCell membrane, Chemotaxis, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Membrane, Polymorphism, Receptor, Reference proteome, Sulfation, Transducer, Transmembrane, Transmembrane helix
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)8.4< 0.05RNA microarray18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis)6.4< 0.05RNA microarray18187931
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.90.000000833RNA microarray19698090
Exp20706631Mus musculus6kidneyglomerular capillary endothelial cellDiabetes (diabetic nephropathy)0.38< 0.05RNA microarray20706631
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.79< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.7< 0.05RNA microarray21752957
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.38< 0.05RNA-seq23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)2.02< 0.05RNA-seq23757392
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.049762673LC-MS/MS24172336
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.370.000252RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium