CKDdb-logoCKDdb - Molecule ID A9248

geneAHR, BHLHE76
nameAryl hydrocarbon receptor precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AHR_HUMANP35869ENSG00000106546196Hs.171189600253

Functions and classifications

GOC:cytosolic aryl hydrocarbon receptor complex, C:nucleus, C:transcription factor complex, F:Hsp90 protein binding, F:ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, F:protein heterodimerization activity, F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, F:sequence-specific DNA binding, F:signal transducer activity, F:transcription regulatory region DNA binding, P:apoptotic process, P:blood vessel development, P:cell cycle, P:negative regulation of transcription from RNA polymerase II promoter, P:positive regulation of RNA polymerase II transcriptional preinitiation complex assembly, P:prostate gland development, P:regulation of B cell proliferation, P:response to stress, P:xenobiotic metabolic process, P:cellular response to glucocorticoid stimulus, P:ovarian follicle development, P:response to estradiol stimulus
UniProtAcetylation, Activator, Cell cycle, Complete proteome, Cytoplasm, DNA-binding, Nucleus, Polymorphism, Receptor, Reference proteome, Repeat, Transcription, Transcription regulation
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.570.00000108RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.2< 0.05RNA microarray21752957
Exp23505438aHomo sapiens kidneyproximal tubular cellsDiabetes (diabetic nephropathy)0.580.006cDNA microarray23505438
Exp23505438bHomo sapiens kidneyproximal tubular cellsDiabetes (diabetic nephropathy)0.490.026cDNA microarray23505438

Compile date 08-10-2018© iMODE-CKD consortium