CKDdb-logoCKDdb - Molecule ID A9244

geneADORA1
nameAdenosine A1 receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AA1R_HUMANP30542ENSG00000163485134Hs.77867102775

Functions and classifications

GOC:asymmetric synapse, C:axolemma, C:basolateral plasma membrane, C:dendrite, C:endomembrane system, C:endoplasmic reticulum, C:integral component of plasma membrane, C:neuronal cell body, C:postsynaptic density, C:postsynaptic membrane, C:presynaptic active zone, C:presynaptic membrane, C:terminal bouton, F:G-protein coupled adenosine receptor activity, F:phospholipase C activity, F:purine nucleoside binding, P:activation of MAPKK activity, P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, P:apoptotic signaling pathway, P:cell-cell signaling, P:cognition, P:detection of temperature stimulus involved in sensory perception of pain, P:inflammatory response, P:lipid catabolic process, P:negative regulation of acute inflammatory response, P:negative regulation of apoptotic process, P:negative regulation of blood pressure, P:negative regulation of cardiac muscle contraction, P:negative regulation of cell proliferation, P:negative regulation of circadian sleep/wake cycle, non-REM sleep, P:negative regulation of glutamate secretion, P:negative regulation of heart contraction, P:negative regulation of hormone secretion, P:negative regulation of leukocyte migration, P:negative regulation of lipid catabolic process, P:negative regulation of mucus secretion, P:negative regulation of neurotrophin production, P:negative regulation of renal sodium excretion, P:negative regulation of synaptic transmission, GABAergic, P:negative regulation of synaptic transmission, glutamatergic, P:negative regulation of vasodilation, P:nervous system development, P:phagocytosis, P:positive regulation of blood pressure, P:positive regulation of epidermal growth factor-activated receptor activity, P:positive regulation of nucleoside transport, P:positive regulation of peptide secretion, P:positive regulation of potassium ion transport, P:positive regulation of protein dephosphorylation, P:protein targeting to membrane, P:regulation of excitatory postsynaptic membrane potential, P:regulation of glomerular filtration, P:regulation of respiratory gaseous exchange by neurological system process, P:regulation of synaptic plasticity, P:relaxation of vascular smooth muscle, P:response to hypoxia, P:temperature homeostasis, C:integral component of membrane, C:integral to plasma membrane, C:terminal button, C:integral to membrane
UniProtAlternative splicing, Cell membrane, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Lipoprotein, Membrane, Palmitate, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.340.000177RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.340.00661RNA microarray19698090
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.3< 0.05RNA microarray21752957
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium