CKDdb-logoCKDdb - Molecule ID A8898

geneAVP, ARVP, VP
nameVasopressin-neurophysin 2-copeptin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
NEU2_HUMANP01185ENSG00000101200551Hs.89648125700, 192340

Functions and classifications

GOC:cytosol, C:dendrite, C:extracellular region, C:extracellular space, C:secretory granule, F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process, F:neuropeptide hormone activity, F:protein kinase activity, F:signal transducer activity, P:cell-cell signaling, P:ERK1 and ERK2 cascade, P:generation of precursor metabolites and energy, P:grooming behavior, P:hyperosmotic salinity response, P:locomotory behavior, P:maternal aggressive behavior, P:maternal behavior, P:multicellular organismal water homeostasis, P:negative regulation of apoptotic process, P:negative regulation of female receptivity, P:negative regulation of release of cytochrome c from mitochondria, P:negative regulation of transmission of nerve impulse, P:penile erection, P:positive regulation of cAMP biosynthetic process, P:positive regulation of cell growth, P:positive regulation of cell proliferation, P:positive regulation of cellular pH reduction, P:positive regulation of cytosolic calcium ion concentration, P:positive regulation of gene expression, P:positive regulation of glutamate secretion, P:positive regulation of peptidyl-serine phosphorylation, P:positive regulation of prostaglandin biosynthetic process, P:positive regulation of systemic arterial blood pressure, P:positive regulation of vasoconstriction, P:protein kinase C signaling, P:regulation of renal sodium excretion, P:response to ethanol, P:response to nicotine, P:response to testosterone, P:social behavior, P:sodium-independent organic anion transport, P:transmembrane transport, P:vasoconstriction, P:water transport, P:elevation of cytosolic calcium ion concentration, P:protein kinase C signaling cascade
UniProtAmidation, Cleavage on pair of basic residues, Complete proteome, Diabetes insipidus, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Hormone, Polymorphism, Reference proteome, Secreted, Signal, Vasoactive, Vasoconstrictor
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.0000744RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium