CKDdb-logoCKDdb - Molecule ID A8783

geneAHSG, FETUA, PRO2743
nameAlpha-2-HS-glycoprotein precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
FETUA_HUMANP02765ENSG00000145192197Hs.324746138680

Functions and classifications

GOC:extracellular space, F:cysteine-type endopeptidase inhibitor activity, F:kinase inhibitor activity, P:acute-phase response, P:negative regulation of bone mineralization, P:negative regulation of endopeptidase activity, P:negative regulation of insulin receptor signaling pathway, P:ossification, P:pinocytosis, P:positive regulation of phagocytosis, P:regulation of inflammatory response, P:skeletal system development, C:extracellular matrix, C:protein complex, F:receptor signaling protein tyrosine kinase inhibitor activity, P:cellular response to insulin stimulus, P:cerebral cortex development, P:male gonad development, P:negative regulation of cell growth, P:organ regeneration, P:positive regulation of bone resorption
UniProtComplete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Mineral balance, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Secreted, Signal
PADBunknown

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.0143nanoLC-ESI-MS/MS17301227
Exp17327332aHomo sapiens42urinewholeDiabetes (Diabetic Nephropathy)4.71< 0.05LC-MS/MS17327332
Exp17327332bHomo sapiens42urinewholeDiabetes (Diabetic Nephropathy)2.32< 0.05LC-MS/MS17327332
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)29.40.05RNA microarray17579666
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)1.67 LC-MS/MS18440303
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.0123RNA microarray19698090
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp22498882Homo sapiens10urinewholeGlomerulonephritis (lupus nephritis) < 0.0001ESI-Q-TOF MS/MS22498882
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)1.690hybrid quadrupole-TOF, LC-MS/MS22536212
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)2.25 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23464927Homo sapiens10urine Fabry (12 months of ERT)2.74<0.05QTOF MS/MS23464927
Exp24096133aHomo sapiens10urine>10kDaDiabetes (type 1 diabetes without retinopathy or nephropathy)0 1DE, MALDI24096133
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)0.5 1DE, MALDI24096133
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)0 1DE, MALDI24096133
Exp24096133dHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)0 1DE, MALDI24096133
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)3.03< 0.05LC-MS/MS24497609
Exp24798088Rattus norvegicus kidney AKI (AKI)65.530.004MS/MS24798088
Exp24927646aMus musculus16kidney Diabetes (diabetic nephropathy treated with Phlorizin)1.93< 0.05LC-MS/MS24927646
Exp24927646bMus musculus16kidney Diabetes (diabetic nephropathy)3.03< 0.05LC-MS/MS24927646

Compile date 08-10-2018© iMODE-CKD consortium