CKDdb-logoCKDdb - Molecule ID A8721

geneC4B, C4B12, C4B-1
nameComplement C4-B precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CO4B_HUMANP0C0L5ENSG00000228454100293534Hs.534847120820, 152700, 614374, 614379

Functions and classifications

GOC:extracellular region, C:extracellular space, C:plasma membrane, F:endopeptidase inhibitor activity, P:complement activation, P:complement activation, classical pathway, P:inflammatory response, P:innate immune response, P:negative regulation of endopeptidase activity, P:regulation of complement activation
UniProtBlood group antigen, Cleavage on pair of basic residues, Complement pathway, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Immunity, Inflammatory response, Innate immunity, Polymorphism, Reference proteome, Secreted, Signal, Sulfation, Systemic lupus erythematosus, Thioester bond
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.5nanoLC-ESI-MS/MS17301227
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.130.000115RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.0000511RNA microarray19698090
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) 0.0023LC-MS/MS20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) 1.00E-04LC-MS/MS20411046
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.320.000731195NGS, RNA-seq.22266139
Exp22891811aHomo sapiens10urinewholeureteral_obstruction (congenital bilateral hydronephrosis)0.56 +/- 0.049 < 0.05LC-MS/MS22891811
Exp23143504Homo sapiens urinewholeAKI (AKI)382.680.01LC-MS/MS23143504
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)1.40.00003LC-MS/MS23228063
Exp23326503Rattus norvegicus kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)7.134.18E-08mRNA microarray23326503
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.69< 0.05RNA-seq23757392
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.7< 0.05RNA-seq23757392
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)3.03< 0.05RNA-seq23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)2.1< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium