CKDdb-logoCKDdb - Molecule ID A8720

geneC4A, CO4, CPAMD2
nameComplement C4 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CO4A_HUMANP0C0L4ENSG00000206340720Hs.534847120790, 120810, 152700, 614374, 614380

Functions and classifications

GOC:extracellular region, C:extracellular space, C:plasma membrane, F:endopeptidase inhibitor activity, P:complement activation, P:complement activation, classical pathway, P:inflammatory response, P:innate immune response, P:negative regulation of endopeptidase activity, P:regulation of complement activation
UniProt3D-structure, Alternative splicing, Blood group antigen, Cleavage on pair of basic residues, Complement pathway, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Immunity, Inflammatory response, Innate immunity, Polymorphism, Reference proteome, Secreted, Signal, Sulfation, Systemic lupus erythematosus, Thioester bond
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp16083269Rattus norvegicus10bloodserumTransplantation (Acute Renal Allograft Rejection)up< 0.05SELDI-MS (CM10, Q10), MALDI-MS/MS16083269
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)0.31 LC-MS/MS18440303
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.130.000115RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.0000511RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.331.50E-05RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.383.00E-05RNA microarray20019191
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) 1.00E-04LC-MS/MS20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) 1.00E-04LC-MS/MS20411046
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection)3.050.2788LC-MS/MS20812764
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)2.89< 0.001MALDI-TOF/TOF21544065
Exp21544065cRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.3< 0.001MALDI-TOF/TOF21544065
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.6< 0.05RNA microarray21752957
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)1.570.0102QSTAR Elite LC-MS/MS22172726
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.260.000324823NGS, RNA-seq.22266139
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)0.87 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23577616Homo sapiens urinewholeGlomerulonephritis (IgA nephropathy)5.740.001MALDI-TOF-MS23577616
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)4.11.10E-06LC-MS25150443

Compile date 08-10-2018© iMODE-CKD consortium