CKDdb-logoCKDdb - Molecule ID A8668

geneARHGEF10
nameRho guanine nucleotide exchange factor 10
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARHGA_HUMANO15013ENSG000001047289639Hs.98594608136, 608236

Functions and classifications

GOC:centrosome, C:cytosol, F:Rho guanyl-nucleotide exchange factor activity, P:centrosome duplication, P:myelination in peripheral nervous system, P:positive regulation of GTP catabolic process, P:positive regulation of stress fiber assembly, P:spindle assembly involved in mitosis, P:regulation of Rho GTPase activity, P:regulation of Rho protein signal transduction, C:intracellular
UniProtAlternative splicing, Coiled coil, Complete proteome, Disease mutation, Guanine-nucleotide releasing factor, Phosphoprotein, Polymorphism, Reference proteome
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.450.0342475RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.220.0101RNA microarray19698090
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)2.390cDNA microarray21411733
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.440cDNA microarray21411733
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.14< 0.05RNA microarray21752957
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.480.0000028RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium