CKDdb-logoCKDdb - Molecule ID A8667

geneArhgef6
nameRho guanine nucleotide exchange factor 6
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARHG6_MOUSEQ8K4I3ENSMUSG0000003113373341Mm.261443300267, 300436

Functions and classifications

GOC:cell-cell junction, C:lamellipodium, F:protein binding, F:Rho guanyl-nucleotide exchange factor activity, P:intracellular signal transduction, P:lamellipodium assembly, C:cell-cell junction, F:Rho guanyl-nucleotide exchange factor activity, P:intracellular signal transduction, C:cell-cell junction, C:cell-cell junction, C:cytoplasm, F:Rho guanyl-nucleotide exchange factor activity, P:intracellular signal transduction, C:cell-cell junction, C:cytoplasm, F:Rho guanyl-nucleotide exchange factor activity, P:intracellular signal transduction
UniProt3D-structure, Cell projection, Complete proteome, Guanine-nucleotide releasing factor, Phosphoprotein, Reference proteome, SH3 domain
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.293.23E-06RNA microarray20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.86< 0.05RNA microarray21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.049762673LC-MS/MS24172336
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.230.000128RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium